Phenotypes associated with this allele

• Allele Symbol: Golm1^{Gt(KST273)Byg}
• Allele Name: gene trap KST273, BayGenomics
• Allele ID: MGI:4124004
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Golm1^Gt(KST273)Byg/Golm1^Gt(KST273)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:4353893

Genotype
MGI:4353893

hm1

• Allelic Composition: Golm1^{Gt(KST273)Byg}/Golm1^{Gt(KST273)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:151282 )

• beginning at 3 weeks, mice exhibit a progressive decrease in survival that is more pronounced in females

• survival at 18 months is reduced to 87% in males compared to 100% in wild-type mice

• survival at 18 months is reduced to 51% in females compared to 80% in wild-type mice

• premature death is preceded by a 3 week period of moderate weight loss, rough coat, and lethargy

renal/urinary system

kidney inflammation ( J:151282 )

• more females than male mice (40% vs 19%) exhibit inflammatory cell infiltrates at the cortical-medullary junction unlike wild-type mice

abnormal kidney morphology ( J:151282 )

• kidney abnormalities increase in frequency with age

• at 6 months, 90% of mice exhibit renal pathology

abnormal renal glomerular capsule morphology ( J:151282 )

• mice develop fibrotic thickening of Bowman's capsules unlike wild-type mice

glomerulosclerosis ( J:151282 )

• mice develop focal segmental glomerulosclerosis and PAS+ glomerular hyaline thrombi that is more common in females than in males (40% vs 15%)

renal glomerulus hypertrophy ( J:151282 )

• however, glomerular filtration is normal

• mice exhibit glomerular hypertrophy unlike in wild-type mice

kidney atrophy ( J:151282 )

abnormal proximal convoluted tubule morphology ( J:151282 )

• more males than females (75% vs 13%) exhibit degenerative changes in proximal tubules unlike in wild-type mice

renal cast ( J:151282 )

• mice exhibit renal intratubular casts

pale kidney ( J:151282 )

liver/biliary system

liver inflammation ( J:151282 )

• mice frequently develop lobular and periportal inflammation unlike in wild-type mice

abnormal hepatocyte morphology ( J:151282 )

• hepatocytes exhibit membrane irregularities and intranuclear inclusions unlike in wild-type mice

hepatic steatosis ( J:151282 )

• mice develop microvesicular and mixed pattern hepatic steatosis

growth/size/body

weight loss ( J:151282 )

• premature death is preceded by a 3 week period of moderate weight loss, rough coat, and lethargy

behavior/neurological

lethargy ( J:151282 )

• premature death is preceded by a 3 week period of moderate weight loss, rough coat, and lethargy

immune system

liver inflammation ( J:151282 )

• mice frequently develop lobular and periportal inflammation unlike in wild-type mice

kidney inflammation ( J:151282 )

• more females than male mice (40% vs 19%) exhibit inflammatory cell infiltrates at the cortical-medullary junction unlike wild-type mice

integument

rough coat ( J:151282 )

• premature death is preceded by a 3 week period of moderate weight loss, rough coat, and lethargy

homeostasis/metabolism

abnormal glomerular capillary thrombosis ( J:151282 )

• mice develop PAS+ glomerular hyaline thrombi