Phenotypes associated with this allele

• Allele Symbol: Tmtc3^{Gt(JST185)Byg}
• Allele Name: gene trap JST185, BayGenomics
• Allele ID: MGI:4124060
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmtc3^Gt(JST185)Byg/Tmtc3^Gt(JST185)Byg	involves: 129P2/OlaHsd * A/J	MGI:5304370
hm2	Tmtc3^Gt(JST185)Byg/Tmtc3^Gt(JST185)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:5304369

Genotype
MGI:5304370

hm1

• Allelic Composition: Tmtc3^{Gt(JST185)Byg}/Tmtc3^{Gt(JST185)Byg}
• Genetic Background: involves: 129P2/OlaHsd * A/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:178869 )

• due to respiratory failure

respiratory system

abnormal lung development ( J:178869 )

• impaired secondary septation

• bronchial myogenesis and alveolar myofibroblast development are impaired

abnormal branching involved in lung morphogenesis ( J:178869 )

• branching morphogenesis is disrupted during the pseudoglandular stage

impaired lung alveolus development ( J:178869 )

• at P9, mice exhibit abnormal alveolization with dilated distal air sacs and reduced number of terminal airspaces

abnormal lung bud morphology ( J:178869 )

• at E13.5 and E14.5, distal epithelial buds are dilated with reduced branching compared to in wild-type mice

overexpanded pulmonary alveolus ( J:178869 )

• with few secondary septations at 3 weeks of age

respiratory failure ( J:178869 )

• in some mice

growth/size/body

postnatal growth retardation ( J:178869 )

• in surviving mice

cellular

abnormal cell differentiation ( J:178869 )

• mouse embryonic fibroblasts exhibit impaired development into myofibroblasts

homeostasis/metabolism

cyanosis ( J:178869 )

• in some mice

Genotype
MGI:5304369

hm2

• Allelic Composition: Tmtc3^{Gt(JST185)Byg}/Tmtc3^{Gt(JST185)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

postnatal lethality, incomplete penetrance ( J:178869 )

• due to respiratory failure

respiratory system

abnormal lung development ( J:178869 )

• impaired secondary septation

• bronchial myogenesis and alveolar myofibroblast development are impaired

abnormal branching involved in lung morphogenesis ( J:178869 )

• branching morphogenesis is disrupted during the pseudoglandular stage

impaired lung alveolus development ( J:178869 )

• at P9, mice exhibit abnormal alveolization with dilated distal air sacs and reduced number of terminal airspaces

abnormal lung bud morphology ( J:178869 )

• at E13.5 and E14.5, distal epithelial buds are dilated with reduced branching compared to in wild-type mice

overexpanded pulmonary alveolus ( J:178869 )

• with few secondary septations at 3 weeks of age

respiratory failure ( J:178869 )

• in some mice

growth/size/body

postnatal growth retardation ( J:178869 )

• in surviving mice

cellular

abnormal cell differentiation ( J:178869 )

• mouse embryonic fibroblasts exhibit impaired development into myofibroblasts

homeostasis/metabolism

cyanosis ( J:178869 )

• in some mice