All Phenotypes Mtdh<Gt(XB780)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mtdh^Gt(XB780)Byg
gene trap XB780, BayGenomics
MGI:4124379

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mtdh^Gt(XB780)Byg/Mtdh^Gt(XB780)Byg	FVB.129P2-Mtdh^Gt(XB780)Byg	MGI:5649037
cx2	Mtdh^Gt(XB780)Byg/Mtdh^Gt(XB780)Byg Tg(MMTVneu)202Mul/0	FVB.Cg-Mtdh^Gt(XB780)Byg Tg(MMTVneu)202Mul	MGI:5661728
cx3	Mtdh^Gt(XB780)Byg/Mtdh^Gt(XB780)Byg Tg(MMTV-PyVT)634Mul/0	FVB.Cg-Mtdh^Gt(XB780)Byg Tg(MMTV-PyVT)634Mul	MGI:5649039
cx4	Mtdh^Gt(XB780)Byg/Mtdh⁺ Tg(MMTV-PyVT)634Mul/0	FVB.Cg-Mtdh^Gt(XB780)Byg Tg(MMTV-PyVT)634Mul	MGI:5649043
cx5	Mtdh^Gt(XB780)Byg/Mtdh^Gt(XB780)Byg Tg(Wnt1)1Hev/0	FVB.Cg-Mtdh^Gt(XB780)Byg Tg(Wnt1)1Hev	MGI:5649041
cx6	Mtdh^Gt(XB780)Byg/Mtdh⁺ Tg(Wnt1)1Hev/0	FVB.Cg-Mtdh^Gt(XB780)Byg Tg(Wnt1)1Hev	MGI:5649042

Allelic Composition	Mtdh^Gt(XB780)Byg/Mtdh^Gt(XB780)Byg
Genetic Background	FVB.129P2-Mtdh^Gt(XB780)Byg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtdh^Gt(XB780)Byg mutation (0 available); any Mtdh mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:214244 )

• increased time of tumor free survival following treatment with medroxyprogesterone acetate (MPA) and 7, 12-dimethylbenzanthracene (DMBA)

neoplasm

decreased incidence of tumors by chemical induction ( J:214244 )

• decreased mammary tumor incidence following treatment with medroxyprogesterone acetate (MPA) and 7, 12-dimethylbenzanthracene (DMBA)

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:214244 )

• transient delay in ductal outgrowth from 3 to 5 weeks of age

• however, no significant differences are detected at later time points or during pregnancy and lactation

reproductive system

reproductive system phenotype ( J:214244 )

• fertile

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:214244 )

• increased time of tumor free survival following treatment with medroxyprogesterone acetate (MPA) and 7, 12-dimethylbenzanthracene (DMBA)

decreased incidence of tumors by chemical induction ( J:214244 )

• decreased mammary tumor incidence following treatment with medroxyprogesterone acetate (MPA) and 7, 12-dimethylbenzanthracene (DMBA)

integument

abnormal branching of the mammary ductal tree ( J:214244 )

• transient delay in ductal outgrowth from 3 to 5 weeks of age

• however, no significant differences are detected at later time points or during pregnancy and lactation

Allelic Composition	Mtdh^Gt(XB780)Byg/Mtdh^Gt(XB780)Byg Tg(MMTVneu)202Mul/0
Genetic Background	FVB.Cg-Mtdh^Gt(XB780)Byg Tg(MMTVneu)202Mul

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtdh^Gt(XB780)Byg mutation (0 available); any Mtdh mutation (33 available)
Tg(MMTVneu)202Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased mammary gland tumor incidence ( J:214244 )

• by 300 days of age only 60% of mice develop tumors while almost all transgenic mice wild-type for Mtdh have tumors by this age

• by 18 months of age, 30% of mice are tumor free

decreased metastatic potential ( J:214244 )

• lung metastasis are severely reduced

increased tumor latency ( J:214244 )

• by 300 days of age only 60% of mice develop tumors while almost all transgenic mice wild-type for Mtdh have tumors by this age

• by 18 months of age, 30% of mice are tumor free

integument

decreased mammary gland tumor incidence ( J:214244 )

• by 300 days of age only 60% of mice develop tumors while almost all transgenic mice wild-type for Mtdh have tumors by this age

• by 18 months of age, 30% of mice are tumor free

mammary gland hyperplasia ( J:214244 )

• only 20% of mice are mildly hyperplastic while 100% of transgenic mice wild-type for Mtdh display hyperplasia at 6 months of age

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:214244 )

• by 300 days of age only 60% of mice develop tumors while almost all transgenic mice wild-type for Mtdh have tumors by this age

• by 18 months of age, 30% of mice are tumor free

mammary gland hyperplasia ( J:214244 )

• only 20% of mice are mildly hyperplastic while 100% of transgenic mice wild-type for Mtdh display hyperplasia at 6 months of age

Allelic Composition	Mtdh^Gt(XB780)Byg/Mtdh^Gt(XB780)Byg Tg(MMTV-PyVT)634Mul/0
Genetic Background	FVB.Cg-Mtdh^Gt(XB780)Byg Tg(MMTV-PyVT)634Mul

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtdh^Gt(XB780)Byg mutation (0 available); any Mtdh mutation (33 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased mammary gland tumor incidence ( J:214244 )

• total tumor burden is reduced to 10% of transgenic mice wild-type for Mtdh

abnormal tumor pathology ( J:214244 )

• isolated mammary epithelial cells from preneoplastic glands contain fewer tumor initiating cells

decreased metastatic potential ( J:214244 )

• mice have fewer and smaller metastatic nodules compared to transgenic mice wild-type for Mtdh

increased tumor latency ( J:214244 )

• mammary tumors are detected by 50 days of age and 50% of mice have tumors after 80 days of age, later than in transgenic mice wild-type for Mtdh

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:214244 )

• total tumor burden is reduced to 10% of transgenic mice wild-type for Mtdh

mammary gland hyperplasia ( J:214244 )

• display fewer and smaller hyperplastic foci at 4 weeks of age compared to transgenic mice wild-type for Mtdh

integument

decreased mammary gland tumor incidence ( J:214244 )

• total tumor burden is reduced to 10% of transgenic mice wild-type for Mtdh

mammary gland hyperplasia ( J:214244 )

• display fewer and smaller hyperplastic foci at 4 weeks of age compared to transgenic mice wild-type for Mtdh

Allelic Composition	Mtdh^Gt(XB780)Byg/Mtdh⁺ Tg(MMTV-PyVT)634Mul/0
Genetic Background	FVB.Cg-Mtdh^Gt(XB780)Byg Tg(MMTV-PyVT)634Mul

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtdh^Gt(XB780)Byg mutation (0 available); any Mtdh mutation (33 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased mammary gland tumor incidence ( J:214244 )

• total tumor burden is reduced to 54% of transgenic mice wild-type for Mtdh

integument

decreased mammary gland tumor incidence ( J:214244 )

• total tumor burden is reduced to 54% of transgenic mice wild-type for Mtdh

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:214244 )

• total tumor burden is reduced to 54% of transgenic mice wild-type for Mtdh

Allelic Composition	Mtdh^Gt(XB780)Byg/Mtdh^Gt(XB780)Byg Tg(Wnt1)1Hev/0
Genetic Background	FVB.Cg-Mtdh^Gt(XB780)Byg Tg(Wnt1)1Hev

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtdh^Gt(XB780)Byg mutation (0 available); any Mtdh mutation (33 available)
Tg(Wnt1)1Hev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased mammary gland tumor incidence ( J:214244 )

• no tumors are detected in 62% of mice at 300 days of age unlike in transgenic mice wild-type for Mtdh

• the number of tumors in mice with tumors is also reduced compared to transgenic mice wild-type for Mtdh

increased tumor latency ( J:214244 )

• no tumors are detected in 62% of mice at 300 days of age unlike in transgenic mice wild-type for Mtdh

integument

decreased mammary gland tumor incidence ( J:214244 )

• no tumors are detected in 62% of mice at 300 days of age unlike in transgenic mice wild-type for Mtdh

• the number of tumors in mice with tumors is also reduced compared to transgenic mice wild-type for Mtdh

mammary gland hyperplasia ( J:214244 )

• display fewer and smaller hyperplastic foci at 4 weeks of age compared to transgenic mice wild-type for Mtdh

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:214244 )

• no tumors are detected in 62% of mice at 300 days of age unlike in transgenic mice wild-type for Mtdh

• the number of tumors in mice with tumors is also reduced compared to transgenic mice wild-type for Mtdh

mammary gland hyperplasia ( J:214244 )

• display fewer and smaller hyperplastic foci at 4 weeks of age compared to transgenic mice wild-type for Mtdh

Allelic Composition	Mtdh^Gt(XB780)Byg/Mtdh⁺ Tg(Wnt1)1Hev/0
Genetic Background	FVB.Cg-Mtdh^Gt(XB780)Byg Tg(Wnt1)1Hev

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtdh^Gt(XB780)Byg mutation (0 available); any Mtdh mutation (33 available)
Tg(Wnt1)1Hev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased mammary gland tumor incidence ( J:214244 )

• no tumors are detected in 35% of mice at 300 days of age unlike in transgenic mice wild-type for Mtdh

• the number of tumors in mice with tumors is also reduced compared to transgenic mice wild-type for Mtdh

increased tumor latency ( J:214244 )

• no tumors are detected in 35% of mice at 300 days of age unlike in transgenic mice wild-type for Mtdh

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:214244 )

• no tumors are detected in 35% of mice at 300 days of age unlike in transgenic mice wild-type for Mtdh

• the number of tumors in mice with tumors is also reduced compared to transgenic mice wild-type for Mtdh

integument

decreased mammary gland tumor incidence ( J:214244 )

• no tumors are detected in 35% of mice at 300 days of age unlike in transgenic mice wild-type for Mtdh

• the number of tumors in mice with tumors is also reduced compared to transgenic mice wild-type for Mtdh

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