All Phenotypes Tnrc6a<Gt(XE786)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tnrc6a^Gt(XE786)Byg
gene trap XE786, BayGenomics
MGI:4124681

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnrc6a^Gt(XE786)Byg/Tnrc6a^Gt(XE786)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:5315770

Allelic Composition	Tnrc6a^Gt(XE786)Byg/Tnrc6a^Gt(XE786)Byg
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnrc6a^Gt(XE786)Byg mutation (0 available); any Tnrc6a mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Embryonic lethality and yolk sac defects in Tnrc6a^Gt(XE786)Byg/Tnrc6a^Gt(XE786)Byg mice

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:182447 )

• most mice mice die between E9.5 and E12.5

hematopoietic system

impaired hematopoiesis ( J:182447 )

decreased hematopoietic cell number ( J:182447 )

• in the yolk sac

decreased erythrocyte cell number ( J:182447 )

• at E9.5

embryo

abnormal visceral yolk sac blood island morphology ( J:182447 )

• blood islands are smaller with fewer hematopoietic cells compared to in wild-type mice

abnormal extraembryonic endoderm formation ( J:182447 )

• thin endoderm layer in the yolk sac at E9.5

integument

pallor ( J:182447 )

• pale at E9.5

cellular

decreased cell proliferation ( J:182447 )

• in the yolk sac endoderm and mesoderm

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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