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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zfp157Gt(XC356)Byg
gene trap XC356, BayGenomics
MGI:4124834
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zfp157Gt(XC356)Byg/Zfp157Gt(XC356)Byg involves: 129P2/OlaHsd MGI:5427846
cn2
 		Gata3tm1Jfz/Gata3tm1Jfz
Zfp157Gt(XC356)Byg/Zfp157Gt(XC356)Byg
Tg(LGB-cre)74Acl/0 		involves: 129 * C57BL/6 * CBA MGI:5427847


Genotype
MGI:5427846
hm1
Allelic
Composition		 Zfp157Gt(XC356)Byg/Zfp157Gt(XC356)Byg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp157Gt(XC356)Byg mutation (0 available); any Zfp157 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal mammary gland growth during pregnancy ( J:184505 )
• increased alveolar density at all stages investigated with the most marked difference at 5dG
• increase in the number of actively proliferating cells at 5dG

integument
abnormal mammary gland morphology ( J:184505 )
• decrease in the number of progesterone receptor expressing cells and increase in the number of STAT5 expressing cells
abnormal mammary gland development ( J:184505 )
• at 5 weeks of age the leading edge of the terminal end buds is significantly past the lymph node unlike in controls
• however, at 8 weeks of age there is no observable difference from controls
• no alteration in mammary gland development is seen during lactation or involution
abnormal mammary gland growth during pregnancy ( J:184505 )
• increased alveolar density at all stages investigated with the most marked difference at 5dG
• increase in the number of actively proliferating cells at 5dG
mammary gland alveolar hyperplasia ( J:184505 )
• increased alveolar density at all stages investigated with the most marked difference at 5 dG
abnormal mammary gland physiology ( J:184505 )
• decrease in the expression of the milk protein gene, Wap

endocrine/exocrine glands
abnormal mammary gland morphology ( J:184505 )
• decrease in the number of progesterone receptor expressing cells and increase in the number of STAT5 expressing cells
abnormal mammary gland development ( J:184505 )
• at 5 weeks of age the leading edge of the terminal end buds is significantly past the lymph node unlike in controls
• however, at 8 weeks of age there is no observable difference from controls
• no alteration in mammary gland development is seen during lactation or involution
abnormal mammary gland growth during pregnancy ( J:184505 )
• increased alveolar density at all stages investigated with the most marked difference at 5dG
• increase in the number of actively proliferating cells at 5dG
mammary gland alveolar hyperplasia ( J:184505 )
• increased alveolar density at all stages investigated with the most marked difference at 5 dG
abnormal mammary gland physiology ( J:184505 )
• decrease in the expression of the milk protein gene, Wap




Genotype
MGI:5427847
cn2
Allelic
Composition		 Gata3tm1Jfz/Gata3tm1Jfz
Zfp157Gt(XC356)Byg/Zfp157Gt(XC356)Byg
Tg(LGB-cre)74Acl/0
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata3tm1Jfz mutation (0 available); any Gata3 mutation (31 available)
Tg(LGB-cre)74Acl mutation (2 available)
Zfp157Gt(XC356)Byg mutation (0 available); any Zfp157 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:184505 )
N
• rescue of the lactation failure seen in mutant mice wild-type for Zfp157

integument
abnormal mammary gland luminal epithelium morphology ( J:184505 )
• mild epithelial dysplasia in all ducts and alveoli with an increase in the number of binucleate cells and cells of variable sizes

endocrine/exocrine glands
abnormal mammary gland luminal epithelium morphology ( J:184505 )
• mild epithelial dysplasia in all ducts and alveoli with an increase in the number of binucleate cells and cells of variable sizes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory