Phenotypes associated with this allele

• Allele Symbol: Pdlim1^Gt(XC262)Byg
• Allele Name: gene trap XC262, BayGenomics
• Allele ID: MGI:4124892
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdlim1^Gt(XC262)Byg/Pdlim1^Gt(XC262)Byg	involves: 129P2/OlaHsd	MGI:5578592

Genotype
MGI:5578592

hm1

• Allelic Composition: Pdlim1^Gt(XC262)Byg/Pdlim1^Gt(XC262)Byg
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:212221 )

N • mice exhibit normal megakaryopoiesis and platelet production

increased mean platelet volume ( J:212221 )

• slight

abnormal platelet physiology ( J:212221 )

• in response to GPVI agonists (collagen-related peptide and convulxin), platelets exhibit increased aggregation, enhanced dense granule secretionincreased calcium mobilization and faster, increased ATP release compared with wild-type cells

• however, response to GPCR agonists ADP, thrombin and the stable thromboxane A2 analog U46619 is normal

increased platelet aggregation ( J:212221 )

• in response to GPVI agonists (collagen-related peptide and convulxin)

• in platelets on collagen under flow

abnormal platelet dense granule physiology ( J:212221 )

• enhanced dense granule secretion in response to GPVI agonists (collagen-related peptide and convulxin)

homeostasis/metabolism

abnormal platelet physiology ( J:212221 )

• in response to GPVI agonists (collagen-related peptide and convulxin), platelets exhibit increased aggregation, enhanced dense granule secretionincreased calcium mobilization and faster, increased ATP release compared with wild-type cells

• however, response to GPCR agonists ADP, thrombin and the stable thromboxane A2 analog U46619 is normal

increased platelet aggregation ( J:212221 )

• in response to GPVI agonists (collagen-related peptide and convulxin)

• in platelets on collagen under flow

abnormal platelet dense granule physiology ( J:212221 )

• enhanced dense granule secretion in response to GPVI agonists (collagen-related peptide and convulxin)

abnormal thrombosis ( J:212221 )

• accelerated arterial thrombus formation in a bone marrow cell transfer experiment

• however, bleeding times are normal