All Phenotypes Kcmf1<Gt(XE080)Byg> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kcmf1^Gt(XE080)Byg
gene trap XE080, BayGenomics
MGI:4124894

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcmf1^Gt(XE080)Byg/Kcmf1^Gt(XE080)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:4818399
cx2	Kcmf1^Gt(XE080)Byg/Kcmf1^Gt(XE080)Byg Tg(Mt1-Tgfa)149Bri/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL	MGI:4818401

Allelic Composition	Kcmf1^Gt(XE080)Byg/Kcmf1^Gt(XE080)Byg
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcmf1^Gt(XE080)Byg mutation (0 available); any Kcmf1 mutation (110 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:162125 )

• fewer than expected mice survive to adulthood

• however, mice that reach adulthood exhibit normal survival through 360 days of observation

perinatal lethality, incomplete penetrance ( J:162125 )

• fewer than expected mice are born alive

postnatal lethality, incomplete penetrance ( J:162125 )

• fewer than expected mice survive to adulthood

Allelic Composition	Kcmf1^Gt(XE080)Byg/Kcmf1^Gt(XE080)Byg Tg(Mt1-Tgfa)149Bri/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcmf1^Gt(XE080)Byg mutation (0 available); any Kcmf1 mutation (110 available)
Tg(Mt1-Tgfa)149Bri mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreas morphology ( J:162125 )

• at 6 and 12 months, mice exhibit reduced number and size of tubular complexes compared with Tg(Mt1-Tgfa)149Bri mice

decreased pancreas weight ( J:162125 )

• compared with Tg(Mt1-Tgfa)149Bri mice

abnormal pancreas physiology ( J:162125 )

• proliferation of pancreatic ductal cells is reduced compared to in Tg(Mt1-Tgfa)149Bri mice

neoplasm

decreased tumor incidence ( J:162125 )

• unlike Tg(Mt1-Tgfa)149Bri mice, no malignant transformation are observed in the pancreas

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24