All Phenotypes Kcmf1<Gt(XE080)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kcmf1^Gt(XE080)Byg
gene trap XE080, BayGenomics
MGI:4124894

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcmf1^Gt(XE080)Byg/Kcmf1^Gt(XE080)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:4818399
cx2	Kcmf1^Gt(XE080)Byg/Kcmf1^Gt(XE080)Byg Tg(Mt1-Tgfa)149Bri/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL	MGI:4818401

Allelic Composition	Kcmf1^Gt(XE080)Byg/Kcmf1^Gt(XE080)Byg
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcmf1^Gt(XE080)Byg mutation (0 available); any Kcmf1 mutation (110 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:162125 )

• fewer than expected mice survive to adulthood

• however, mice that reach adulthood exhibit normal survival through 360 days of observation

perinatal lethality, incomplete penetrance ( J:162125 )

• fewer than expected mice are born alive

postnatal lethality, incomplete penetrance ( J:162125 )

• fewer than expected mice survive to adulthood

Allelic Composition	Kcmf1^Gt(XE080)Byg/Kcmf1^Gt(XE080)Byg Tg(Mt1-Tgfa)149Bri/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcmf1^Gt(XE080)Byg mutation (0 available); any Kcmf1 mutation (110 available)
Tg(Mt1-Tgfa)149Bri mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreas morphology ( J:162125 )

• at 6 and 12 months, mice exhibit reduced number and size of tubular complexes compared with Tg(Mt1-Tgfa)149Bri mice

decreased pancreas weight ( J:162125 )

• compared with Tg(Mt1-Tgfa)149Bri mice

abnormal pancreas physiology ( J:162125 )

• proliferation of pancreatic ductal cells is reduced compared to in Tg(Mt1-Tgfa)149Bri mice

neoplasm

decreased tumor incidence ( J:162125 )

• unlike Tg(Mt1-Tgfa)149Bri mice, no malignant transformation are observed in the pancreas

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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