Phenotypes associated with this allele

• Allele Symbol: Dlc1^Gt(XE082)Byg
• Allele Name: gene trap XE082, BayGenomics
• Allele ID: MGI:4124985
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dlc1^Gt(XE082)Byg/Dlc1^Gt(XE082)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:5447390

Genotype
MGI:5447390

hm1

• Allelic Composition: Dlc1^Gt(XE082)Byg/Dlc1^Gt(XE082)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Yolk sac and neural tube abnormalities in Dlc1^Gt(XE082)Byg/Dlc1^Gt(XE082)Byg embryos

mortality/aging

prenatal lethality, complete penetrance ( J:189950 )

• no mice are born

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:189950 )

• severely reduced embryonic and placental vasculature

• aggregated erythrocytes in collapsed blood vessels of the placenta

abnormal vitelline vasculature morphology ( J:189950 )

abnormal heart atrium morphology ( J:189950 )

• thin and underdeveloped walls

enlarged heart ( J:189950 )

• at E10.5 to E11.5

thin ventricular wall ( J:189950 )

• thin and underdeveloped

embryo

abnormal vitelline vasculature morphology ( J:189950 )

embryonic growth retardation ( J:189950 )

• at E10.5 to E11.5

abnormal neural tube morphology ( J:189950 )

• open and contorted at E10.5 to E11.5

open neural tube ( J:189950 )

• at E10.5 to E11.5

embryo tissue necrosis ( J:189950 )

• necrotic embryos at E10.5 to E11.5

abnormal placenta labyrinth morphology ( J:189950 )

• bloodless

abnormal placental labyrinth vasculature morphology ( J:189950 )

• severely reduced embryonic and placental vasculature

• aggregated erythrocytes in collapsed blood vessels of the placenta

pale yolk sac ( J:189950 )

cellular

increased fibroblast cell migration ( J:189950 )

• in a scratch assay, mouse embryonic fibroblast cells exhibit enhanced wound healing due to increased motility compared with wild-type cells

hematopoietic system

abnormal blood cell morphology/development ( J:189950 )

• lack of blood cells in the heart, yolk sac and placental labyrinth

growth/size/body

enlarged heart ( J:189950 )

• at E10.5 to E11.5

embryonic growth retardation ( J:189950 )

• at E10.5 to E11.5

homeostasis/metabolism

enhanced wound healing ( J:189950 )

• in a scratch assay, mouse embryonic fibroblast cells exhibit enhanced wound healing due to increased motility compared with wild-type cells

nervous system

abnormal neural tube morphology ( J:189950 )

• open and contorted at E10.5 to E11.5

open neural tube ( J:189950 )

• at E10.5 to E11.5

delayed brain development ( J:189950 )

• at E10.5 to E11.5