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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sf1Gt(XD130)Byg
gene trap XD130, BayGenomics
MGI:4124998
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sf1Gt(XD130)Byg/Sf1Gt(XD130)Byg involves: 129P2/OlaHsd * 129S1/SvImJ MGI:4836910
ht2
 		Sf1Gt(XD130)Byg/Sf1+ involves: 129P2/OlaHsd * 129S1/SvImJ * MOLF/Ei MGI:4836912
cx3
 		Dnd1Ter/Dnd1Ter
Sf1Gt(XD130)Byg/Sf1+ 		involves: 129P2/OlaHsd * 129S1/SvImJ * 129T1/Sv MGI:4836911


Genotype
MGI:4836910
hm1
Allelic
Composition		 Sf1Gt(XD130)Byg/Sf1Gt(XD130)Byg
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/SvImJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sf1Gt(XD130)Byg mutation (0 available); any Sf1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:164224 )
• no embryos are observed at E.11.5 or weaning




Genotype
MGI:4836912
ht2
Allelic
Composition		 Sf1Gt(XD130)Byg/Sf1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/SvImJ * MOLF/Ei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sf1Gt(XD130)Byg mutation (0 available); any Sf1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased testis tumor incidence ( J:164224 )
• reduced Testicular germ cell tumor incidence compared with that of the control 129 consomic Chr19 MOLF strain

reproductive system
increased testis tumor incidence ( J:164224 )
• reduced Testicular germ cell tumor incidence compared with that of the control 129 consomic Chr19 MOLF strain

endocrine/exocrine glands
increased testis tumor incidence ( J:164224 )
• reduced Testicular germ cell tumor incidence compared with that of the control 129 consomic Chr19 MOLF strain




Genotype
MGI:4836911
cx3
Allelic
Composition		 Dnd1Ter/Dnd1Ter
Sf1Gt(XD130)Byg/Sf1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/SvImJ * 129T1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnd1Ter mutation (1 available); any Dnd1 mutation (16 available)
Sf1Gt(XD130)Byg mutation (0 available); any Sf1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased testis tumor incidence ( J:164224 )
• bilateral testicular tumor numbers decrease compared to Dnd1Ter single mutant
decreased tumor incidence ( J:164224 )
• only 40% of mice develop testis tumor compared to Dnd1Ter single mutant

endocrine/exocrine glands
small testis ( J:164224 )
• increase in number of bilateral small testes compared to Dnd1Ter single mutant
increased testis tumor incidence ( J:164224 )
• bilateral testicular tumor numbers decrease compared to Dnd1Ter single mutant

reproductive system
small testis ( J:164224 )
• increase in number of bilateral small testes compared to Dnd1Ter single mutant
increased testis tumor incidence ( J:164224 )
• bilateral testicular tumor numbers decrease compared to Dnd1Ter single mutant
male infertility ( J:164224 )
• increase in number of sterile mice compared to Dnd1Ter single mutant




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory