Phenotypes associated with this allele

• Allele Symbol: Tspan3^{Gt(NPX312)Byg}
• Allele Name: gene trap NPX312, BayGenomics
• Allele ID: MGI:4125242
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tspan3^Gt(NPX312)Byg/Tspan3^Gt(NPX312)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:5775126

Genotype
MGI:5775126

hm1

• Allelic Composition: Tspan3^{Gt(NPX312)Byg}/Tspan3^{Gt(NPX312)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased hematopoietic stem cell number ( J:231800 )

• 40-60% reduction in bone marrow cells (hematopoietic progenitors and differentiated cells) at 3 months of age

neoplasm

decreased leukemia incidence ( J:231800 )

• mice transplanted with hematopoietic stem/progenitor cells (KLS - c-Kit+Lin-Sca-1+) infected with MLL-AF9/NRAS exhibit increased survival (53% versus 10%) as compared to mice transplanted with similarly treated wild-type cells