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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Glg1Gt(RST092)Byg
gene trap RST092, BayGenomics
MGI:4125299
Summary 3 genotypes


Genotype
MGI:5699556
hm1
Allelic
Composition
Glg1Gt(RST092)Byg/Glg1Gt(RST092)Byg
Genetic
Background
B6J.129P2-Glg1Gt(RST092)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glg1Gt(RST092)Byg mutation (0 available); any Glg1 mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no homozygotes are obtained at E10.5-E15.5 or at weaning




Genotype
MGI:5699558
ht2
Allelic
Composition
Glg1Gt(RST092)Byg/Glg1+
Genetic
Background
B6J.129P2-Glg1Gt(RST092)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glg1Gt(RST092)Byg mutation (0 available); any Glg1 mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• at 4 days after i.p. thioglycollate injection, 10-wk-old heterozygotes exhibit significantly decreased intraperitoneal leukocytes relative to wild-type controls
• following challenge with local TNF injection, 8-wk-old male heterozygotes show significantly decreased numbers of firmly attached leukocytes on endothelial cells in cremaster venules relative to wild-type controls
• following challenge with local TNF injection, 8-wk-old male heterozygotes show increased numbers of rolling leukocytes in cremaster venules relative to wild-type controls

hematopoietic system
• at 4 days after i.p. thioglycollate injection, 10-wk-old heterozygotes exhibit significantly decreased intraperitoneal leukocytes relative to wild-type controls
• following challenge with local TNF injection, 8-wk-old male heterozygotes show significantly decreased numbers of firmly attached leukocytes on endothelial cells in cremaster venules relative to wild-type controls
• following challenge with local TNF injection, 8-wk-old male heterozygotes show increased numbers of rolling leukocytes in cremaster venules relative to wild-type controls

cellular
• at 4 days after i.p. thioglycollate injection, 10-wk-old heterozygotes exhibit significantly decreased intraperitoneal leukocytes relative to wild-type controls
• following challenge with local TNF injection, 8-wk-old male heterozygotes show significantly decreased numbers of firmly attached leukocytes on endothelial cells in cremaster venules relative to wild-type controls
• following challenge with local TNF injection, 8-wk-old male heterozygotes show increased numbers of rolling leukocytes in cremaster venules relative to wild-type controls

cardiovascular system
N
• heterozygotes are viable and develop normally with no apparent phenotypic abnormalities in the unchallenged state
• at 18 weeks of age, heterozygotes fed a high-fat, high-sucrose diet for 10 weeks display an impaired endothelial-dependent relaxation response to acetylcholine, that is similar in extent to that seen in wild-type controls




Genotype
MGI:5699561
cx3
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Glg1Gt(RST092)Byg/Glg1+
Genetic
Background
B6J.129P2-Apoetm1Unc Glg1Gt(RST092)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Glg1Gt(RST092)Byg mutation (0 available); any Glg1 mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• mice exhibit no significant differences in right and left ventricular chamber thickness or in myocardial collagen deposition relative to Apoetm1Unc homozygotes
• after 9 weeks on a Western diet, mice exhibit atherosclerotic lesions with increased collagen deposition and fewer macrophages per mm2 of lesion relative to lesions from Apoetm1Unc homozygotes, as shown by collagen-specific (Sirius Red) and macrophage-specific (CD68) staining of aortic valves
• altered lesion composition suggests increased plaque stability; however, no differences in lesion area and thickness or in accumulation of smooth muscle cells are observed relative to Apoetm1Unc homozygotes

immune system
• after 9 weeks on a Western diet, mice exhibit a significantly reduced macrophage content in atherosclerotic lesions relative to Apoetm1Unc homozygotes
• mice exhibit a significantly reduced macrophage content and CD68 expression in liver tissue relative to Apoetm1Unc homozygotes

hematopoietic system
• after 9 weeks on a Western diet, mice exhibit a significantly reduced macrophage content in atherosclerotic lesions relative to Apoetm1Unc homozygotes
• mice exhibit a significantly reduced macrophage content and CD68 expression in liver tissue relative to Apoetm1Unc homozygotes

homeostasis/metabolism
• after 9 weeks on a Western diet, mice exhibit significantly increased collagen deposition in atherosclerotic lesions relative to Apoetm1Unc homozygotes

cellular
• after 9 weeks on a Western diet, mice exhibit a significantly reduced macrophage content in atherosclerotic lesions relative to Apoetm1Unc homozygotes





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory