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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kdm6bGt(XB814)Byg
gene trap XB814, BayGenomics
MGI:4125312
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kdm6bGt(XB814)Byg/Kdm6bGt(XB814)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:5491455
cn2
 		Gt(ROSA)26Sortm1(Kdm6b)Scla/Gt(ROSA)26Sor+
Kdm6bGt(XB814)Byg/Kdm6bGt(XB814)Byg
Tg(Pgk1-cre)1Lni/0 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:5491456
cx3
 		Kdm6bGt(XB814)Byg/Kdm6bGt(XB814)Byg
Tg(Kdm6b*H1388A)21Gtes/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:5491457


Genotype
MGI:5491455
hm1
Allelic
Composition		 Kdm6bGt(XB814)Byg/Kdm6bGt(XB814)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6bGt(XB814)Byg mutation (0 available); any Kdm6b mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:196346 )
• mice die shortly after birth unable to breath

nervous system
abnormal pre-Botzinger complex morphology ( J:196346 )
• disrupted formation and maintenance of the pre-Botzinger complex
abnormal nervous system physiology ( J:196346 )
• the respiratory rhythm generator fails to produce rhythmic phrenic bursts unlike in wild-type mice
• electrical shock fails to stimulate phrenic motor neurons unlike in wild-type mice
• medullary stimulation fails to induce phrenic bursts unlike in wild-type mice
• application of acidified artificial cerebrospinal fluid with or without serotonin or norepinephrine or elevated concentrations of potassium fails to induce rhythmic phrenic burst unlike in wild-type mice
• however, medullary stimulation commonly induced brief responses of phrenic motor neurons
abnormal pre-Botzinger complex physiology ( J:196346 )
• disrupted formation and maintenance of the pre-Botzinger complex

respiratory system
respiratory system phenotype ( J:196346 )
N
• lung development and inflation of alveolar space are normal

cardiovascular system
cardiovascular system phenotype ( J:196346 )
N
• normal heart beat at E18.5

homeostasis/metabolism
cyanosis ( J:196346 )
• at birth




Genotype
MGI:5491456
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(Kdm6b)Scla/Gt(ROSA)26Sor+
Kdm6bGt(XB814)Byg/Kdm6bGt(XB814)Byg
Tg(Pgk1-cre)1Lni/0
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Kdm6b)Scla mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Kdm6bGt(XB814)Byg mutation (0 available); any Kdm6b mutation (67 available)
Tg(Pgk1-cre)1Lni mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:196346 )
N
• neonatal lethality observed in Kdm6bGt(XB814)Byg homozygotes is rescued

nervous system
nervous system phenotype ( J:196346 )
N
• mice exhibit normal pre-Botzinger complex




Genotype
MGI:5491457
cx3
Allelic
Composition		 Kdm6bGt(XB814)Byg/Kdm6bGt(XB814)Byg
Tg(Kdm6b*H1388A)21Gtes/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6bGt(XB814)Byg mutation (0 available); any Kdm6b mutation (67 available)
Tg(Kdm6b*H1388A)21Gtes mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:196346 )
• while present at E18.5, no mice are recovered at weaning




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory