All Phenotypes Zfp42<Gt(XB238)Byg> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp42^Gt(XB238)Byg/Zfp42^Gt(XB238)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:4942410
ht2	Zfp42^Gt(XB238)Byg/Zfp42⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:4942411

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:169234 )

• when heterozygotes are intercrossed some fraction of homozygote and heterozygote embryos die during gestation

• the number of males is reduced relative to the number of females

embryonic lethality, incomplete penetrance ( J:169234 )

• embryos with hypermethylated differentially methylated regions die before E14.5

cellular

abnormal DNA methylation ( J:169234 )

• hypermethylation of the differentially methylated regions associated with the Peg3 and Nespas loci is detected in some null blastocysts but not in sperm

abnormal imprinting ( J:169234 )

• hypermethylation of the differentially methylated regions associated with the Peg3 and Nespas loci is detected in some null blastocysts but not in sperm

reproductive system

decreased litter size ( J:169234 )

• crosses of male or female homozygotes to wild-type mice results in smaller litters compared to wild-type to wild-type crosses

• the reduction in litter size is more dramatic when male homozygous mice are crossed to wild-type mice relative to the inverse cross

• decrease in litter size is correlated with combined parental gene dosage

Allelic Composition	Zfp42^Gt(XB238)Byg/Zfp42⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp42^Gt(XB238)Byg mutation (0 available); any Zfp42 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype