About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sema4bGt(RST235)Byg
gene trap RST235, BayGenomics
MGI:4125445
Summary 3 genotypes


Genotype
MGI:5807141
hm1
Allelic
Composition
Sema4bGt(RST235)Byg/Sema4bGt(RST235)Byg
Genetic
Background
B6.129P2-Sema4bGt(RST235)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema4bGt(RST235)Byg mutation (1 available); any Sema4b mutation (298 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
N
• mice show normal kidney morphology and a normal response to kidney ischemia/reperfusion injury




Genotype
MGI:4881707
hm2
Allelic
Composition
Sema4bGt(RST235)Byg/Sema4bGt(RST235)Byg
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema4bGt(RST235)Byg mutation (1 available); any Sema4b mutation (298 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit no cerebellar phenotypes




Genotype
MGI:5807148
cx3
Allelic
Composition
Sema4bGt(RST235)Byg/Sema4bGt(RST235)Byg
Sema4dtm1Kik/Sema4dtm1Kik
Sema4gtm1Kik/Sema4gtm1Kik
Genetic
Background
B6.Cg-Sema4bGt(RST235)Byg Sema4dtm1Kik Sema4gtm1Kik
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema4bGt(RST235)Byg mutation (1 available); any Sema4b mutation (298 available)
Sema4dtm1Kik mutation (2 available); any Sema4d mutation (88 available)
Sema4gtm1Kik mutation (0 available); any Sema4g mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• following renal ischemia/reperfusion injury, mice exhibit misorganized, multi-layered tubular kidney epithelium compared to controls
• tubular defects after kidney injury are confined to the outer renal medulla

renal/urinary system
• following renal ischemia/reperfusion injury, mice exhibit misorganized, multi-layered tubular kidney epithelium compared to controls
• tubular defects after kidney injury are confined to the outer renal medulla
• following renal ischemia/reperfusion injury, mice exhibit misorganized, multi-layered tubular kidney epithelium compared to controls
• however, mice are viable and show no overt defects in kidney histology under normal conditions





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/19/2024
MGI 6.24
The Jackson Laboratory