All Phenotypes Sema4b<Gt(RST235)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sema4b^{Gt(RST235)Byg}
gene trap RST235, BayGenomics
MGI:4125445

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sema4b^{Gt(RST235)Byg}/Sema4b^{Gt(RST235)Byg}	B6.129P2-Sema4b^{Gt(RST235)Byg}	MGI:5807141
hm2	Sema4b^{Gt(RST235)Byg}/Sema4b^{Gt(RST235)Byg}	involves: 129P2/OlaHsd	MGI:4881707
cx3	Sema4b^{Gt(RST235)Byg}/Sema4b^{Gt(RST235)Byg} Sema4d^tm1Kik/Sema4d^tm1Kik Sema4g^tm1Kik/Sema4g^tm1Kik	B6.Cg-Sema4b^{Gt(RST235)Byg} Sema4d^tm1Kik Sema4g^tm1Kik	MGI:5807148

Allelic Composition	Sema4b^{Gt(RST235)Byg}/Sema4b^{Gt(RST235)Byg}
Genetic Background	B6.129P2-Sema4b^{Gt(RST235)Byg}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema4b^{Gt(RST235)Byg} mutation (1 available); any Sema4b mutation (298 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:221423 )

N	• mice show normal kidney morphology and a normal response to kidney ischemia/reperfusion injury

Allelic Composition	Sema4b^{Gt(RST235)Byg}/Sema4b^{Gt(RST235)Byg}
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema4b^{Gt(RST235)Byg} mutation (1 available); any Sema4b mutation (298 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:167973 )

N	• mice exhibit no cerebellar phenotypes

Allelic Composition	Sema4b^{Gt(RST235)Byg}/Sema4b^{Gt(RST235)Byg} Sema4d^tm1Kik/Sema4d^tm1Kik Sema4g^tm1Kik/Sema4g^tm1Kik
Genetic Background	B6.Cg-Sema4b^{Gt(RST235)Byg} Sema4d^tm1Kik Sema4g^tm1Kik

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema4b^{Gt(RST235)Byg} mutation (1 available); any Sema4b mutation (298 available)
Sema4d^tm1Kik mutation (2 available); any Sema4d mutation (88 available)
Sema4g^tm1Kik mutation (0 available); any Sema4g mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased susceptibility to kidney reperfusion injury ( J:221423 )

• following renal ischemia/reperfusion injury, mice exhibit misorganized, multi-layered tubular kidney epithelium compared to controls

• tubular defects after kidney injury are confined to the outer renal medulla

renal/urinary system

increased susceptibility to kidney reperfusion injury ( J:221423 )

• following renal ischemia/reperfusion injury, mice exhibit misorganized, multi-layered tubular kidney epithelium compared to controls

• tubular defects after kidney injury are confined to the outer renal medulla

abnormal renal tubule epithelium morphology ( J:221423 )

• following renal ischemia/reperfusion injury, mice exhibit misorganized, multi-layered tubular kidney epithelium compared to controls

• however, mice are viable and show no overt defects in kidney histology under normal conditions

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