Phenotypes associated with this allele

• Allele Symbol: Rnf7^Gt(XE423)Byg
• Allele Name: gene trap XE423, BayGenomics
• Allele ID: MGI:4125996
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rnf7^Gt(XE423)Byg/Rnf7^Gt(XE423)Byg	involves: 129P2/OlaHsd	MGI:4836044
hm2	Rnf7^Gt(XE423)Byg/Rnf7^Gt(XE423)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:5301657
cn3	Kras^tm4Tyj/Kras^+ Rnf7^Gt(XE423)Byg/Rnf7^tm1.1Ysun	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:5562910
cn4	Kras^tm4Tyj/Kras^+ Rnf7^Gt(XE423)Byg/Rnf7^+	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:5562914
cx5	Nf1^tm1Par/Nf1^tm1Par Rnf7^Gt(XE423)Byg/Rnf7^Gt(XE423)Byg	involves: 129 * C57BL/6	MGI:5301658

Genotype
MGI:4836044

hm1

• Allelic Composition: Rnf7^Gt(XE423)Byg/Rnf7^Gt(XE423)Byg
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased cellular sensitivity to ionizing radiation ( J:164457 )

• a derived embryonic stem line exposed to radiation exhibits decreased survival compared with similarly treated wild-type cells

increased apoptosis ( J:164457 )

• a derived embryonic stem line exposed to radiation exhibits increased apoptosis compared with similarly treated wild-type cells

oxidative stress ( J:164457 )

• a derived embryonic stem line exposed to radiation exhibits increased reactive oxygen species generation compared with similarly treated wild-type cells

Genotype
MGI:5301657

hm2

• Allelic Composition: Rnf7^Gt(XE423)Byg/Rnf7^Gt(XE423)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

nervous system

increased spinal cord apoptosis ( J:178926 )

• increased apoptosis in the developing spinal cord

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:178926 )

• die between E11.5 and E12.5

homeostasis/metabolism

pericardial edema ( J:178926 )

• frequently seen in embryos at E10.5

embryo

abnormal vitelline vasculature morphology ( J:178926 )

• disrupted vasculature with missing major blood vessels and disorganized secondary branches at E9.5 and E10.5

increased embryonic tissue cell apoptosis ( J:178926 )

• widespread apoptosis in embryos at E10.5

embryonic growth retardation ( J:178926 )

• at E10.5

abnormal visceral yolk sac blood island morphology ( J:178926 )

• decrease in the number of red blood cells in the blood islands

cellular

abnormal cell cycle ( J:178926 )

• impairment of cell cycle progression in neuronal precursor cells in the neocortex

increased embryonic tissue cell apoptosis ( J:178926 )

• widespread apoptosis in embryos at E10.5

increased spinal cord apoptosis ( J:178926 )

• increased apoptosis in the developing spinal cord

abnormal cell differentiation ( J:178926 )

• cultured embryonic stem cells fail to differentiate into cystic embryoid bodies

decreased cell proliferation ( J:178926 )

• teratomas derived from embryonic stem cells grow more slowly

• decrease in proliferation of neuronal precursor cells in the neocortex

cardiovascular system

decreased angiogenesis ( J:178926 )

• decrease in the number of blood vessels surrounding and within the neuroepithelium

abnormal vitelline vasculature morphology ( J:178926 )

• disrupted vasculature with missing major blood vessels and disorganized secondary branches at E9.5 and E10.5

pericardial edema ( J:178926 )

• frequently seen in embryos at E10.5

growth/size/body

embryonic growth retardation ( J:178926 )

• at E10.5

Genotype
MGI:5562910

cn3

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Rnf7^Gt(XE423)Byg/Rnf7^tm1.1Ysun
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

mortality/aging

premature death ( J:207982 )

• median survival time of Ad-Cre treated mice is 37.9 weeks, with most mice dying by 60 weeks

neoplasm

decreased lung tumor incidence ( J:207982 )

• mice show reduced lung tumor burden following intratracheal administration of an adenovirus expressing Cre (Ad-Cre) compared to single Kras homozygotes, however the number of hyperplastic loci is not affected

• hyperplasia or adenomas from Ad-Cre treated mice show reduced proliferation compared to single Kras homozygotes

respiratory system

decreased lung tumor incidence ( J:207982 )

• mice show reduced lung tumor burden following intratracheal administration of an adenovirus expressing Cre (Ad-Cre) compared to single Kras homozygotes, however the number of hyperplastic loci is not affected

• hyperplasia or adenomas from Ad-Cre treated mice show reduced proliferation compared to single Kras homozygotes

Genotype
MGI:5562914

cn4

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Rnf7^Gt(XE423)Byg/Rnf7⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

mortality/aging

premature death ( J:207982 )

• median survival time of Ad-Cre treated mice is 27.6 weeks, with all mice dying by 33 weeks

neoplasm

increased lung adenoma incidence ( J:207982 )

• mice develop lung adenomas with a few adenocarcinomas following intratracheal administration of an adenovirus expressing Cre (Ad-Cre)

increased lung adenocarcinoma incidence ( J:207982 )

• a few adenocarcinomas develop in mice following Ad-Cre administration

respiratory system

increased lung adenoma incidence ( J:207982 )

• mice develop lung adenomas with a few adenocarcinomas following intratracheal administration of an adenovirus expressing Cre (Ad-Cre)

increased lung adenocarcinoma incidence ( J:207982 )

• a few adenocarcinomas develop in mice following Ad-Cre administration

Genotype
MGI:5301658

cx5

• Allelic Composition: Nf1^tm1Par/Nf1^tm1Par; Rnf7^Gt(XE423)Byg/Rnf7^Gt(XE423)Byg
• Genetic Background: involves: 129 * C57BL/6

cellular

increased apoptosis ( J:178926 )

• partial rescue of apoptosis in the spinal cord compared to mice null for Rnf7 alone

• rescue of neuronal apoptosis compared to mice null for Rnf7 alone

decreased cell proliferation ( J:178926 )

• decrease in proliferation of neuronal precursor cells in the neocortex

cardiovascular system

abnormal angiogenesis ( J:178926 )

• partial restoration of angiogenesis in the head compared to mice null for Rnf7 alone

embryo

embryonic growth retardation ( J:178926 )

growth/size/body

embryonic growth retardation ( J:178926 )