Phenotypes associated with this allele

• Allele Symbol: Smurf2^{Gt(RRA098)Byg}
• Allele Name: gene trap RRA098, BayGenomics
• Allele ID: MGI:4126344
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smurf2^Gt(RRA098)Byg/Smurf2^Gt(RRA098)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:5446903
ht2	Smurf2^Gt(RRA098)Byg/Smurf2^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5446904

Genotype
MGI:5446903

hm1

• Allelic Composition: Smurf2^{Gt(RRA098)Byg}/Smurf2^{Gt(RRA098)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:189320 )

• mice develop tumors within 20 months

increased small intestine adenocarcinoma incidence ( J:189320 )

• in some mice

increased hepatocellular carcinoma incidence ( J:189320 )

• in some mice

increased lymphoma incidence ( J:189320 )

• lymphomas often spread to the spleen, kidney and liver

increased B cell derived lymphoma incidence ( J:189320 , J:245679 )

• mice begin to develop diffuse large B-cell lymphoma starting at 15 months of age, with variation in formation from 15 to 20 months (J:245679)

• a circulating microRNA signature predicts the development of lymphoma (J:245679)

increased sarcoma incidence ( J:189320 )

• in some mice

digestive/alimentary system

increased small intestine adenocarcinoma incidence ( J:189320 )

• in some mice

cellular

delayed cellular replicative senescence ( J:189320 )

• in mouse embryonic fibroblasts under a 3T9 protocol

• in the spleen of premalignant aged mice

liver/biliary system

increased hepatocellular carcinoma incidence ( J:189320 )

• in some mice

hematopoietic system

enlarged spleen ( J:189320 )

immune system

enlarged spleen ( J:189320 )

growth/size/body

enlarged spleen ( J:189320 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
diffuse large B-cell lymphoma		DOID:0050745		J:245679

Genotype
MGI:5446904

ht2

• Allelic Composition: Smurf2^{Gt(RRA098)Byg}/Smurf2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

neoplasm

increased tumor incidence ( J:189320 )

• mice develop tumors within 20 months

increased lymphoma incidence ( J:189320 )

• in some mice

cellular

delayed cellular replicative senescence ( J:189320 )

• in mouse embryonic fibroblasts under a 3T9 protocol