All Phenotypes Kdm6a<Gt(RRA094)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kdm6a^{Gt(RRA094)Byg}
gene trap RRA094, BayGenomics
MGI:4126347

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kdm6a^{Gt(RRA094)Byg}/Kdm6a^{Gt(RRA094)Byg}	either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)	MGI:5516060
cx2	Kdm6a^{Gt(RRA094)Byg}/Y X/Uty^{Gt(XS0378)Wtsi}	either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)	MGI:5516061
ot3	Kdm6a^{Gt(RRA094)Byg}/Y	chimera involves: 129P2/OlaHsd	MGI:4457140
ot4	Kdm6a^{Gt(RRA094)Byg}/Y	either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)	MGI:5516059

Allelic Composition	Kdm6a^{Gt(RRA094)Byg}/Kdm6a^{Gt(RRA094)Byg}
Genetic Background	either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6a^{Gt(RRA094)Byg} mutation (0 available); any Kdm6a mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:201868 )

• dead and resorbed by E12.5

• found at expected ratios at E10.5

growth/size/body

decreased embryo size ( J:201868 )

• smaller in size at E10.5

nervous system

open neural tube ( J:201868 )

• in the mid brain region at E10.5

cardiovascular system

abnormal cardiovascular development ( J:201868 )

• hearts small and underdeveloped

abnormal heart morphology ( J:201868 )

failure of heart looping ( J:201868 )

• incomplete

thin interventricular septum ( J:201868 )

• poorly formed and incomplete

small heart ( J:201868 )

myocardial trabeculae hypoplasia ( J:201868 )

thin ventricular wall ( J:201868 )

pericardial edema ( J:201868 )

• in more severe cases

embryo

decreased embryo size ( J:201868 )

• smaller in size at E10.5

open neural tube ( J:201868 )

• in the mid brain region at E10.5

pale yolk sac ( J:201868 )

• reduced vascular blood

homeostasis/metabolism

pericardial edema ( J:201868 )

• in more severe cases

muscle

myocardial trabeculae hypoplasia ( J:201868 )

Allelic Composition	Kdm6a^{Gt(RRA094)Byg}/Y X/Uty^{Gt(XS0378)Wtsi}
Genetic Background	either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6a^{Gt(RRA094)Byg} mutation (0 available); any Kdm6a mutation (40 available)
Uty^{Gt(XS0378)Wtsi} mutation (2 available); any Uty mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:201868 )

• no mice recovered at E18.5

• found at expected ratios at E10.5

cardiovascular system

abnormal heart morphology ( J:201868 )

failure of heart looping ( J:201868 )

• incomplete

thin interventricular septum ( J:201868 )

• poorly formed and incomplete

small heart ( J:201868 )

myocardial trabeculae hypoplasia ( J:201868 )

thin ventricular wall ( J:201868 )

pericardial edema ( J:201868 )

• in more severe cases

homeostasis/metabolism

pericardial edema ( J:201868 )

• in more severe cases

muscle

myocardial trabeculae hypoplasia ( J:201868 )

Allelic Composition	Kdm6a^{Gt(RRA094)Byg}/Y
Genetic Background	chimera involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6a^{Gt(RRA094)Byg} mutation (0 available); any Kdm6a mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Kdm6a^{Gt(RRA094)Byg}/Y chimeras at E9.5 exhibit brain and and neural tube defects

nervous system

open neural tube ( J:160967 )

• midline fusion defects

kinked neural tube ( J:160967 )

abnormal brain development ( J:160967 )

• open brain

abnormal forebrain development ( J:160967 )

• forebrain fusion defects

embryo

open neural tube ( J:160967 )

• midline fusion defects

kinked neural tube ( J:160967 )

Allelic Composition	Kdm6a^{Gt(RRA094)Byg}/Y
Genetic Background	either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6a^{Gt(RRA094)Byg} mutation (0 available); any Kdm6a mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:201868 )

• failure to thrive

• a small number of males survive to adulthood

perinatal lethality, incomplete penetrance ( J:201868 )

• hemizygous males are reduced 68% from expected numbers

• numbers at E18.5 were as expected

growth/size/body

decreased birth body size ( J:201868 )

• small at birth

decreased body size ( J:201868 )

• surviving mice remain runted throughout life

nervous system

exencephaly ( J:201868 )

• a few exencephalic fetuses at E18.5

• otherwise, males are phenotypically normal at E18.5

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