Phenotypes associated with this allele

• Allele Symbol: Mtus1^{Gt(RRA048)Byg}
• Allele Name: gene trap RRA048, BayGenomics
• Allele ID: MGI:4126369
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mtus1^Gt(RRA048)Byg/Mtus1^Gt(RRA048)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:5578210

Genotype
MGI:5578210

hm1

• Allelic Composition: Mtus1^{Gt(RRA048)Byg}/Mtus1^{Gt(RRA048)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:212144 )

• some mice die during 12 months of observation

immune system

salivary gland inflammation ( J:212144 )

• in some mice

insulitis ( J:212144 )

• in some mice

increased leukocyte cell number ( J:212144 )

increased lymphocyte cell number ( J:212144 )

lymphoid hyperplasia ( J:212144 )

• some mice exhibit lymphoid hyperplasia in the spleen, kidney, lung, lymph nodes and liver unlike wild-type mice

increased susceptibility to systemic lupus erythematosus ( J:212144 )

• with B cell lymphoproliferative disease

glomerulonephritis ( J:212144 )

• in some mice with wire-loop lesion in one mouse and crescent formation in another mouse

hematopoietic system

anemia ( J:212144 )

• mild

decreased erythrocyte cell number ( J:212144 )

decreased hematocrit ( J:212144 )

decreased hemoglobin content ( J:212144 )

thrombocytopenia ( J:212144 )

increased leukocyte cell number ( J:212144 )

increased lymphocyte cell number ( J:212144 )

cardiovascular system

cardiovascular system phenotype ( J:212144 )

N • mice exhibit normal blood pressure at 10 months

increased heart weight ( J:212144 )

cardiac hypertrophy ( J:212144 )

• in some mice

cellular

abnormal cell morphology ( J:212144 )

• small cell volume in mouse embryonic fibroblast lines

increased cell proliferation ( J:212144 )

• in 1 of 3 mouse embryonic fibroblast lines

growth/size/body

increased heart weight ( J:212144 )

cardiac hypertrophy ( J:212144 )

• in some mice

increased body weight ( J:212144 )

• at 4 and 10 months

neoplasm

increased B cell derived lymphoma incidence ( J:212144 )

• marginal zone B cell lymphoma in one mouse affecting submandibular salivary gland and regional lymph node

renal/urinary system

glomerulonephritis ( J:212144 )

• in some mice with wire-loop lesion in one mouse and crescent formation in another mouse

digestive/alimentary system

salivary gland inflammation ( J:212144 )

• in some mice

endocrine/exocrine glands

salivary gland inflammation ( J:212144 )

• in some mice

insulitis ( J:212144 )

• in some mice