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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Akap12Gt(XE450)Byg
gene trap XE450, BayGenomics
MGI:4126493
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Akap12Gt(XE450)Byg/Akap12Gt(XE450)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:5561202


Genotype
MGI:5561202
hm1
Allelic
Composition
Akap12Gt(XE450)Byg/Akap12Gt(XE450)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap12Gt(XE450)Byg mutation (0 available); any Akap12 mutation (215 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• decreased cardiomyocytes intracellular calcium transients in the absence of and following isoproterenol stimulation
• increased intraventricular septum in the absence of and following isoproterenol stimulation
• left ventricular posterior wall at systole is increased in the absence of and following isoproterenol stimulation
• left ventricular internal dimensions at diastole is decreased
• however, left ventricular internal dimensions at diastole are normal
• in the absence of and following isoproterenol stimulation
• increased ejection fraction, left ventricular shortening and fractional shortening in the absence of and following isoproterenol stimulation
• increased sarcomere fractional shortening in cardiomyocytes in the absence of and following isoproterenol stimulation

muscle
• decreased cardiomyocytes intracellular calcium transients in the absence of and following isoproterenol stimulation
• increased ejection fraction, left ventricular shortening and fractional shortening in the absence of and following isoproterenol stimulation





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory