Analysis Tools
behavior/neurological
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• do not show short-term (within session) habituation in an open field test
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• the number of rearing bouts was reduced in an open field
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• in a water maze based on poor performance during learning and probe trials
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• in a water maze based on poor performance during learning and probe trials
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• high-preference for spending time in the open versus closed arms and spend less time in the center of the maze in an elevated plus maze
• however, no change in thigmotactic behavior is seen in an open field
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• self-grooming was seen in only 1 of 6 mice compared to 6 of 6 wild-type controls
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• in an elevated plus maze more homozygotes fall from the open arms compared to wild-type controls
• fail to display the typical flat posture when walking on an elevated open arm for the first time
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• spend less time in a posture indicative conflictual state and arousal
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• increase in the distance traveled in an open field test
• increase in the number of arm crossings in an elevated plus maze
• increase in dark phase locomotor activity in the home cage
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• decrease in the time spent engaged in social interactions
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• decrease in time spent in social interactions and vocalizations is particularly decreased during the first minute of an encounter with another juvenile mouse
• adults spend less time sniffing an intruder male or female mouse due to shorter average approach times
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• in juvenile mice during a direct reciprocal social interaction in same genotype pairs
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nervous system
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• increase in the amplitude and decrease in the duration of oscillatory events
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• significant decrease in the relative amount of GluN2A-mediated NMDAR evoked excitatory postsynaptic currents in CA1 pyramidal cells
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• significant increase in the average amplitudes but average half width and frequency are similar to controls
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• long term depression induced by low frequency stimulation is impaired in hippocampal CA1 pyramidal cell synapses
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autism spectrum disorder | DOID:0060041 | J:277713 | ||
