Phenotypes associated with this allele

• Allele Symbol: Wtip^Gt(XH617)Byg
• Allele Name: gene trap XH617, BayGenomics
• Allele ID: MGI:4126568
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wtip^Gt(XH617)Byg/Wtip^Gt(XH617)Byg	B6.129P2-Wtip^Gt(XH617)Byg	MGI:7398153
ht2	Wtip^Gt(XH617)Byg/Wtip^+	B6.129P2-Wtip^Gt(XH617)Byg	MGI:7398156
ht3	Wtip^Gt(XH617)Byg/Wtip^+	FVB.129P2(B6)-Wtip^Gt(XH617)Byg	MGI:7398160

Genotype
MGI:7398153

hm1

• Allelic Composition: Wtip^Gt(XH617)Byg/Wtip^Gt(XH617)Byg
• Genetic Background: B6.129P2-Wtip^Gt(XH617)Byg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:327589 )

• no homozygotes are recovered from heterozygous intercrosses at E3.5

Genotype
MGI:7398156

ht2

• Allelic Composition: Wtip^Gt(XH617)Byg/Wtip⁺
• Genetic Background: B6.129P2-Wtip^Gt(XH617)Byg

homeostasis/metabolism

increased urine protein level ( J:327589 )

• at 6 and 24 h after i.p. injection of LPS, 6- to 8-wk-old heterozygotes develop significantly higher levels of proteinuria than similarly treated wild-type controls

increased susceptibility to injury ( J:327589 )

• in response to LPS-induced kidney injury, heterozygotes on the C57BL/6 background develop significantly higher levels of proteinuria at 6 and 24 h after i.p. injection of LPS than similarly treated wild-type controls

• however, heterozygotes on the C57BL/6 background do not develop albuminuria after tail vein injection of adriamycin, similar to wild-type controls

renal/urinary system

renal/urinary system phenotype ( J:327589 )

N • heterozygotes show no evidence of spontaneous proteinuria at 6-8 weeks of age and do not develop glomerular pathology up to 12 months of age

increased urine protein level ( J:327589 )

• at 6 and 24 h after i.p. injection of LPS, 6- to 8-wk-old heterozygotes develop significantly higher levels of proteinuria than similarly treated wild-type controls

Genotype
MGI:7398160

ht3

• Allelic Composition: Wtip^Gt(XH617)Byg/Wtip⁺
• Genetic Background: FVB.129P2(B6)-Wtip^Gt(XH617)Byg

homeostasis/metabolism

increased urine protein level ( J:327589 )

• at 3 days after a single tail vein injection of adriamycin (20 mg/kg), 6- to 8-wk-old heterozygotes exhibit significantly higher levels of albuminuria than similarly treated wild-type controls

increased susceptibility to injury ( J:327589 )

• in response to adriamycin-induced kidney injury, heterozygotes on the FVN background show significantly higher levels of albuminuria, diffuse podocyte foot process effacement, and lower glomerular nephrin expression at 3 days after tail vein injection of adriamycin (20 mg/kg) than similarly treated wild-type controls

• Background Sensitivity: heterozygotes on the C57BL/6 background do not develop albuminuria after tail vein injection of adriamycin

renal/urinary system

increased urine protein level ( J:327589 )

• at 3 days after a single tail vein injection of adriamycin (20 mg/kg), 6- to 8-wk-old heterozygotes exhibit significantly higher levels of albuminuria than similarly treated wild-type controls

podocyte foot process effacement ( J:327589 )

• at 3 days after a single tail vein injection of adriamycin (20 mg/kg), heterozygotes develop diffuse podocyte foot process effacement, unlike similarly treated wild-type controls which retain normal foot process morphology