Phenotypes associated with this allele

• Allele Symbol: Pdlim5^Gt(XH199)Byg
• Allele Name: gene trap XH199, BayGenomics
• Allele ID: MGI:4126899
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdlim5^Gt(XH199)Byg/Pdlim5^Gt(XH199)Byg	B6.129P2-Pdlim5^Gt(XH199)Byg	MGI:5516493
ht2	Pdlim5^Gt(XH199)Byg/Pdlim5^+	B6.129P2-Pdlim5^Gt(XH199)Byg	MGI:5516494

Genotype
MGI:5516493

hm1

• Allelic Composition: Pdlim5^Gt(XH199)Byg/Pdlim5^Gt(XH199)Byg
• Genetic Background: B6.129P2-Pdlim5^Gt(XH199)Byg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:200039 )

• no mice are present at genotyping (no time of death given)

Genotype
MGI:5516494

ht2

• Allelic Composition: Pdlim5^Gt(XH199)Byg/Pdlim5⁺
• Genetic Background: B6.129P2-Pdlim5^Gt(XH199)Byg

behavior/neurological

behavior/neurological phenotype ( J:200039 )

N • untreated mice exhibit normal performance on a rotarod, novelty seeking, social interaction, locomotion and prepulse inhibition

impaired behavioral response to addictive substance ( J:200039 )

• methamphetamine-treated (acute or chronic) mice exhibit reduced enhanced locomotion and impaired prepulse inhibition compared with wild-type mice

behavioral despair ( J:200039 )

• increased immobility in the forced swimming test

• however, treatment with imipramine attenuates immobility time

decreased locomotor activity ( J:200039 )

• methamphetamine-treated (acute or chronic) mice exhibit reduced enhanced locomotion compared with wild-type mice

nervous system

abnormal prepulse inhibition ( J:200039 )

• in methamphetamine-treated (acute or chronic) mice

• however, startle response is normal