All Phenotypes Mcm9<Gt(XG743)Byg> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mcm9^Gt(XG743)Byg/Mcm9^Gt(XG743)Byg	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:5295418
ht2	Mcm9^{Gt(AW0655)Wtsi}/Mcm9^Gt(XG743)Byg	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:5295419

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Germ-cell depletion and loss of spermatogonial stem cells in Mcm9^Gt(XG743)Byg/Mcm9^Gt(XG743)Byg males

mortality/aging

mortality/aging ( J:177420 )

• viable

liver/biliary system

increased hepatocellular carcinoma incidence ( J:177420 )

• increased incidence in males at 1 year of age and all affected mice have multiple hepatocellular carcinomas

reproductive system

reproductive system phenotype ( J:177420 )

N	• males and young females are fertile

abnormal female germ cell morphology ( J:177420 )

• germ cell loss

decreased oocyte number ( J:177420 )

• newborn mice have 82% fewer oocytes

• almost completely absent at 24 weeks of age

abnormal spermatogonia morphology ( J:177420 )

• some (about 5%) seminiferous tubules lack spermatogonia

decreased male germ cell number ( J:177420 )

• progressive germ cell depletion

oligozoospermia ( J:177420 )

• a 67% decrease in epididymal sperm concentration at 12 weeks of age

• despite the decrease in sperm concentration, males are fertile

decreased primordial germ cell number ( J:177420 )

• a 72% decrease of gonocytes in nascent seminiferous tubules

arrest of male meiosis ( J:177420 )

• about 5% of seminiferous tubules contain a cohort of spermatocytes arrested in meiosis

abnormal ovarian follicle number ( J:177420 )

• decrease in the total number of follicles at 6 and 12 weeks of age

decreased primordial ovarian follicle number ( J:177420 )

• nearly devoid of primordial follicles at 6 and 12 weeks of age

increased ovary tumor incidence ( J:177420 )

• at 1 year of age

abnormal seminiferous tubule morphology ( J:177420 )

• some tubules show progressive germ cell depletion, lack spermatogonia or contain a cohort of spermatocytes arrested in meiosis

small testis ( J:177420 )

• detected at puberty and the difference in size compared to controls increases over time

neoplasm

increased tumor incidence ( J:177420 )

• all males develop tumors by 1 year of age

increased ovary tumor incidence ( J:177420 )

• at 1 year of age

increased hepatocellular carcinoma incidence ( J:177420 )

• increased incidence in males at 1 year of age and all affected mice have multiple hepatocellular carcinomas

cellular

abnormal female germ cell morphology ( J:177420 )

• germ cell loss

decreased oocyte number ( J:177420 )

• newborn mice have 82% fewer oocytes

• almost completely absent at 24 weeks of age

abnormal spermatogonia morphology ( J:177420 )

• some (about 5%) seminiferous tubules lack spermatogonia

decreased male germ cell number ( J:177420 )

• progressive germ cell depletion

oligozoospermia ( J:177420 )

• a 67% decrease in epididymal sperm concentration at 12 weeks of age

• despite the decrease in sperm concentration, males are fertile

decreased primordial germ cell number ( J:177420 )

• a 72% decrease of gonocytes in nascent seminiferous tubules

abnormal cell cycle ( J:177420 )

• MEFs show a delay in progression from G0/G1 to S phase following release from serum starvation in the presence of aphidicolin

arrest of male meiosis ( J:177420 )

• about 5% of seminiferous tubules contain a cohort of spermatocytes arrested in meiosis

early cellular replicative senescence ( J:177420 )

• in primary MEFs

spontaneous chromosome breakage ( J:177420 )

• increase in metaphase chromatid breaks

hematopoietic system

abnormal definitive hematopoiesis ( J:177420 )

• circulating micronucleus levels are increased

endocrine/exocrine glands

abnormal ovarian follicle number ( J:177420 )

• decrease in the total number of follicles at 6 and 12 weeks of age

decreased primordial ovarian follicle number ( J:177420 )

• nearly devoid of primordial follicles at 6 and 12 weeks of age

increased ovary tumor incidence ( J:177420 )

• at 1 year of age

abnormal seminiferous tubule morphology ( J:177420 )

• some tubules show progressive germ cell depletion, lack spermatogonia or contain a cohort of spermatocytes arrested in meiosis

small testis ( J:177420 )

• detected at puberty and the difference in size compared to controls increases over time

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:177420

Allelic Composition	Mcm9^{Gt(AW0655)Wtsi}/Mcm9^Gt(XG743)Byg
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm9^{Gt(AW0655)Wtsi} mutation (0 available); any Mcm9 mutation (75 available)
Mcm9^Gt(XG743)Byg mutation (0 available); any Mcm9 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal spermatogonia morphology ( J:177420 )

• some (about 5%) seminiferous tubules lack spermatogonia

decreased male germ cell number ( J:177420 )

• progressive germ cell depletion

oligozoospermia ( J:177420 )

• a 67% decrease in epididymal sperm concentration at 12 weeks of age

• despite the decrease in sperm concentration, males are fertile

arrest of male meiosis ( J:177420 )

• about 5% of seminiferous tubules contain a cohort of spermatocytes arrested in meiosis

mortality/aging

mortality/aging ( J:177420 )

• viable

liver/biliary system

increased hepatocellular carcinoma incidence ( J:177420 )

• increased incidence in males at 1 year of age and all affected mice have multiple hepatocellular carcinomas

reproductive system

abnormal spermatogonia morphology ( J:177420 )

• some (about 5%) seminiferous tubules lack spermatogonia

decreased male germ cell number ( J:177420 )

• progressive germ cell depletion

oligozoospermia ( J:177420 )

• a 67% decrease in epididymal sperm concentration at 12 weeks of age

• despite the decrease in sperm concentration, males are fertile

arrest of male meiosis ( J:177420 )

• about 5% of seminiferous tubules contain a cohort of spermatocytes arrested in meiosis

increased ovary tumor incidence ( J:177420 )

• at 1 year of age

abnormal seminiferous tubule morphology ( J:177420 )

• some tubules show progressive germ cell depletion, lack spermatogonia or contain a cohort of spermatocytes arrested in meiosis

small testis ( J:177420 )

• detected at puberty and the difference in size compared to controls increases over time

neoplasm

increased tumor incidence ( J:177420 )

• all males develop tumors by 1 year of age

increased ovary tumor incidence ( J:177420 )

• at 1 year of age

increased hepatocellular carcinoma incidence ( J:177420 )

• increased incidence in males at 1 year of age and all affected mice have multiple hepatocellular carcinomas

endocrine/exocrine glands

increased ovary tumor incidence ( J:177420 )

• at 1 year of age

abnormal seminiferous tubule morphology ( J:177420 )

• some tubules show progressive germ cell depletion, lack spermatogonia or contain a cohort of spermatocytes arrested in meiosis

small testis ( J:177420 )

• detected at puberty and the difference in size compared to controls increases over time

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:177420

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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