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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Eno4Gt(RRF299)Byg
gene trap RRF299, BayGenomics
MGI:4127723
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Eno4Gt(RRF299)Byg/Eno4Gt(RRF299)Byg either: (involves: 129P2/OlaHsd * 129S6/SvEvTac) or (involves: 129P2/OlaHsd * C57BL/6) MGI:5520094


Genotype
MGI:5520094
hm1
Allelic
Composition		 Eno4Gt(RRF299)Byg/Eno4Gt(RRF299)Byg
Genetic
Background		 either: (involves: 129P2/OlaHsd * 129S6/SvEvTac) or (involves: 129P2/OlaHsd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eno4Gt(RRF299)Byg mutation (0 available); any Eno4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:202075 )
N
• female mice are fertile
abnormal sperm flagellum morphology ( J:202075 )
• splayed distal tip with no defects in the sperm head
• the outer dense fibers are often displaced and disorganized
abnormal sperm axoneme morphology ( J:202075 )
• disrupted in some flagella
abnormal sperm annulus morphology ( J:202075 )
• often absent, vestigial or misplaced
absent sperm annulus ( J:202075 )
• in some sperm
abnormal sperm principal piece morphology ( J:202075 )
• wrapped in a coil and thin
abnormal sperm fibrous sheath morphology ( J:202075 )
• fibrous sheath ribs are irregular in organization and thickness with disorganized aggregates of fibrous sheath components
kinked sperm flagellum ( J:202075 )
• sharp bend at the midpiece and principal piece junction
asthenozoospermia ( J:202075 )
• 2- to 3-fold

endocrine/exocrine glands

cellular
abnormal sperm flagellum morphology ( J:202075 )
• splayed distal tip with no defects in the sperm head
• the outer dense fibers are often displaced and disorganized
abnormal sperm axoneme morphology ( J:202075 )
• disrupted in some flagella
abnormal sperm annulus morphology ( J:202075 )
• often absent, vestigial or misplaced
absent sperm annulus ( J:202075 )
• in some sperm
abnormal sperm principal piece morphology ( J:202075 )
• wrapped in a coil and thin
abnormal sperm fibrous sheath morphology ( J:202075 )
• fibrous sheath ribs are irregular in organization and thickness with disorganized aggregates of fibrous sheath components
kinked sperm flagellum ( J:202075 )
• sharp bend at the midpiece and principal piece junction
asthenozoospermia ( J:202075 )
• 2- to 3-fold




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory