mortality/aging
• although mice are present at E3.5, no mice are born
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Allele Symbol Allele Name Allele ID |
Atad5Gt(RRF055)Byg gene trap RRF055, BayGenomics MGI:4127920 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• although mice are present at E3.5, no mice are born
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• all mice die between 11 and 20 months with spontaneous tumors or abscesses
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• 20 of 22 mice develop a wide spectrum of spontaneous tumors compared with 4 of 20 wild-type mice
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• granulosa cell tumor
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• in the lymph/lung/liver
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• in the small intestine/stomach
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• in the skeletal muscles, uterus, peripheral nerve, tail, and hindlimb
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• granulosa cell tumor
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• in MMS-treated mouse embryonic fibroblasts
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• gamma-irradiated mice exhibit a 3.3-fold increase in micronucleated reticulocytes compared with 1.4-fold in similarly treated wild-type mice
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• in mouse embryonic fibroblasts treated with MMS
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• MMS-treated mouse embryonic fibroblasts exhibit increased chromatid breaks compared with similarly treated wild-type cells
• gamma-irradiated mice exhibit a 3.3-fold increase in micronucleated reticulocytes compared with 1.4-fold in similarly treated wild-type mice indicating genomic stability
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• granulosa cell tumor
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• gamma-irradiated mice exhibit a 3.3-fold increase in micronucleated reticulocytes compared with 1.4-fold in similarly treated wild-type mice
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• in mouse embryonic fibroblasts treated with MMS
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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