All Phenotypes Aplf<Gt(RRF189)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Aplf^{Gt(RRF189)Byg}
gene trap RRF189, BayGenomics
MGI:4128102

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aplf^{Gt(RRF189)Byg}/Aplf^{Gt(RRF189)Byg}	involves: 129P2/OlaHsd * C57BL/6J	MGI:4888688

Allelic Composition	Aplf^{Gt(RRF189)Byg}/Aplf^{Gt(RRF189)Byg}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplf^{Gt(RRF189)Byg} mutation (1 available); any Aplf mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal DNA repair ( J:168260 )

• B cells exhibit an increased in microhomology at class switch recombination junctions compared with wild-type cells

immune system

abnormal class switch recombination ( J:168260 )

• following gamma irradiation, gamma-H2AX foci decline at a reduced rate in mouse embryonic fibroblasts compared to in wild-type cells

homeostasis/metabolism

abnormal DNA repair ( J:168260 )

• B cells exhibit an increased in microhomology at class switch recombination junctions compared with wild-type cells

hematopoietic system

abnormal class switch recombination ( J:168260 )

• following gamma irradiation, gamma-H2AX foci decline at a reduced rate in mouse embryonic fibroblasts compared to in wild-type cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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