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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
AplfGt(RRF189)Byg
gene trap RRF189, BayGenomics
MGI:4128102
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
AplfGt(RRF189)Byg/AplfGt(RRF189)Byg involves: 129P2/OlaHsd * C57BL/6J MGI:4888688


Genotype
MGI:4888688
hm1
Allelic
Composition
AplfGt(RRF189)Byg/AplfGt(RRF189)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
AplfGt(RRF189)Byg mutation (1 available); any Aplf mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• B cells exhibit an increased in microhomology at class switch recombination junctions compared with wild-type cells

immune system
• following gamma irradiation, gamma-H2AX foci decline at a reduced rate in mouse embryonic fibroblasts compared to in wild-type cells

homeostasis/metabolism
• B cells exhibit an increased in microhomology at class switch recombination junctions compared with wild-type cells

hematopoietic system
• following gamma irradiation, gamma-H2AX foci decline at a reduced rate in mouse embryonic fibroblasts compared to in wild-type cells





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory