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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrig2Gt(RST656)Byg
gene trap RST656, BayGenomics
MGI:4128231
Summary 3 genotypes


Genotype
MGI:5551796
hm1
Allelic
Composition		 Lrig2Gt(RST656)Byg/Lrig2Gt(RST656)Byg
Genetic
Background		 B6N.129P2-Lrig2Gt(RST656)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrig2Gt(RST656)Byg mutation (1 available); any Lrig2 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:202451 )
N
• normal inner ear morphology at E14.5
abnormal auditory brainstem response waveform shape ( J:202451 )
• amplitude of the first wave is significantly diminished in response to a range of frequencies and sound intensities
• latencies are increased
• however, DPOAE and ABR thresholds are similar to controls




Genotype
MGI:5551808
cx2
Allelic
Composition		 Lrig1Gt(GST4169C6)Lex/Lrig1Gt(GST4169C6)Lex
Lrig2Gt(RST656)Byg/Lrig2Gt(RST656)Byg
Genetic
Background		 B6N.129-Lrig2Gt(RST656)Byg Lrig1Gt(GST4169C6)Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrig1Gt(GST4169C6)Lex mutation (0 available); any Lrig1 mutation (50 available)
Lrig2Gt(RST656)Byg mutation (1 available); any Lrig2 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:202451 )
• very few mice survive to 6 weeks of age

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:202451 )
N
• normal ear development
abnormal auditory brainstem response waveform shape ( J:202451 )
• amplitude of the first wave is significantly diminished in response to a range of frequencies and sound intensities
• latencies are increased
• defects are more severe than in single mutants
increased or absent threshold for auditory brainstem response ( J:202451 )
• only respond to sounds greater than 55 dB across all frequencies
increased or absent distortion product otoacoustic emission threshold ( J:202451 )
• only respond to sounds greater than 55 dB across all frequencies

behavior/neurological
circling ( J:202451 )
• seen in half of surviving mice

growth/size/body
decreased body size ( J:202451 )
• runty during adolescence

nervous system
abnormal sensory neuron innervation pattern ( J:202451 )
• overall pattern of cochlear innervation is disrupted
• neurites are noticeably defasciculated and the gaps between the bundles are smaller and present only intermittently
• the inner spiral bundle is reduced
• efferent innervation of the cochlea is reduced




Genotype
MGI:5551809
cx3
Allelic
Composition		 Lrig1Gt(GST4169C6)Lex/Lrig1Gt(GST4169C6)Lex
Lrig2Gt(RST656)Byg/Lrig2+
Genetic
Background		 B6N.129-Lrig2Gt(RST656)Byg Lrig1Gt(GST4169C6)Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrig1Gt(GST4169C6)Lex mutation (0 available); any Lrig1 mutation (50 available)
Lrig2Gt(RST656)Byg mutation (1 available); any Lrig2 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased or absent threshold for auditory brainstem response ( J:202451 )
• only respond to sounds greater than 55 dB across all frequencies
increased or absent distortion product otoacoustic emission threshold ( J:202451 )
• only respond to sounds greater than 55 dB across all frequencies

nervous system
abnormal sensory neuron innervation pattern ( J:202451 )
• disruption of cochlear innervation is not as severe as in double homozygous mice




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory