About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrig2Gt(RST656)Byg
gene trap RST656, BayGenomics
MGI:4128231
Summary 3 genotypes


Genotype
MGI:5551796
hm1
Allelic
Composition		 Lrig2Gt(RST656)Byg/Lrig2Gt(RST656)Byg
Genetic
Background		 B6N.129P2-Lrig2Gt(RST656)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrig2Gt(RST656)Byg mutation (1 available); any Lrig2 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:202451 )
N
• normal inner ear morphology at E14.5
abnormal auditory brainstem response waveform shape ( J:202451 )
• amplitude of the first wave is significantly diminished in response to a range of frequencies and sound intensities
• latencies are increased
• however, DPOAE and ABR thresholds are similar to controls




Genotype
MGI:5551808
cx2
Allelic
Composition		 Lrig1Gt(GST4169C6)Lex/Lrig1Gt(GST4169C6)Lex
Lrig2Gt(RST656)Byg/Lrig2Gt(RST656)Byg
Genetic
Background		 B6N.129-Lrig2Gt(RST656)Byg Lrig1Gt(GST4169C6)Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrig1Gt(GST4169C6)Lex mutation (0 available); any Lrig1 mutation (50 available)
Lrig2Gt(RST656)Byg mutation (1 available); any Lrig2 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:202451 )
• very few mice survive to 6 weeks of age

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:202451 )
N
• normal ear development
abnormal auditory brainstem response waveform shape ( J:202451 )
• amplitude of the first wave is significantly diminished in response to a range of frequencies and sound intensities
• latencies are increased
• defects are more severe than in single mutants
increased or absent threshold for auditory brainstem response ( J:202451 )
• only respond to sounds greater than 55 dB across all frequencies
increased or absent distortion product otoacoustic emission threshold ( J:202451 )
• only respond to sounds greater than 55 dB across all frequencies

behavior/neurological
circling ( J:202451 )
• seen in half of surviving mice

growth/size/body
decreased body size ( J:202451 )
• runty during adolescence

nervous system
abnormal sensory neuron innervation pattern ( J:202451 )
• overall pattern of cochlear innervation is disrupted
• neurites are noticeably defasciculated and the gaps between the bundles are smaller and present only intermittently
• the inner spiral bundle is reduced
• efferent innervation of the cochlea is reduced




Genotype
MGI:5551809
cx3
Allelic
Composition		 Lrig1Gt(GST4169C6)Lex/Lrig1Gt(GST4169C6)Lex
Lrig2Gt(RST656)Byg/Lrig2+
Genetic
Background		 B6N.129-Lrig2Gt(RST656)Byg Lrig1Gt(GST4169C6)Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrig1Gt(GST4169C6)Lex mutation (0 available); any Lrig1 mutation (50 available)
Lrig2Gt(RST656)Byg mutation (1 available); any Lrig2 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased or absent threshold for auditory brainstem response ( J:202451 )
• only respond to sounds greater than 55 dB across all frequencies
increased or absent distortion product otoacoustic emission threshold ( J:202451 )
• only respond to sounds greater than 55 dB across all frequencies

nervous system
abnormal sensory neuron innervation pattern ( J:202451 )
• disruption of cochlear innervation is not as severe as in double homozygous mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory