Phenotypes associated with this allele

• Allele Symbol: Pdia3^{Gt(RST613)Byg}
• Allele Name: gene trap RST613, BayGenomics
• Allele ID: MGI:4128251
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdia3^Gt(RST613)Byg/Pdia3^Gt(RST613)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:4837405
ht2	Pdia3^Gt(RST613)Byg/Pdia3^+	involves: 129P2/OlaHsd * C57BL/6	MGI:4837406

Genotype
MGI:4837405

hm1

• Allelic Composition: Pdia3^{Gt(RST613)Byg}/Pdia3^{Gt(RST613)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:165458 )

• mice are not observed after birth

Genotype
MGI:4837406

ht2

• Allelic Composition: Pdia3^{Gt(RST613)Byg}/Pdia3⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

skeleton

decreased compact bone area ( J:165458 )

• at 15 weeks, mice exhibit decreased cortical bone area compared with wild-type mice

• however, cortical bone thickness is normal

abnormal trabecular bone morphology ( J:165458 )

• at 15 weeks, trabecular space in the distal femoral metaphysis is decreased compared to in wild-type mice

• however, trabecular thickness is normal in the distal femoral metaphysis and trabecular bone in the distal femoral epiphysis is normal

decreased trabecular bone volume ( J:165458 )

• at 15 weeks, mice exhibit increased bone volume to trabecular volume in the distal femoral metaphysis compared with wild-type mice

increased bone trabecula number ( J:165458 )

• at 15 weeks, mice exhibit increased trabecular number compared with wild-type mice