Phenotypes associated with this allele

• Allele Symbol: Chmp2b^Gt(XL952)Byg
• Allele Name: gene trap XL952, BayGenomics
• Allele ID: MGI:4128363
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chmp2b^Gt(XL952)Byg/Chmp2b^Gt(XL952)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:5641375

Genotype
MGI:5641375

hm1

• Allelic Composition: Chmp2b^Gt(XL952)Byg/Chmp2b^Gt(XL952)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampus CA1 region morphology ( J:219860 )

• at 5 weeks of age, the total density of dendritic spines (including thin, stubby, or mushroom types) is reduced by 33% in the CA1-stratum radiatum

• a 33% drop in excitatory synapse density is observed in the CA1-stratum radiatum

abnormal dendritic spine morphology ( J:219860 )

• at 5 weeks of age, the total density of dendritic spines (including thin, stubby, or mushroom types) is reduced by 33% in the stratum radiatum of the hippocampal CA1 region relative to age-matched controls

• in particular, the density of mushroom spines is reduced by 50%

abnormal synapse morphology ( J:219860 )

• at 5 weeks of age, a 33% drop in excitatory synapse density is observed in the stratum radiatum of the hippocampal CA1 region