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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Odf2Gt(XL169)Byg
gene trap XL169, BayGenomics
MGI:4128382
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Odf2Gt(XL169)Byg/Odf2+ chimera involves: 129P2/OlaHsd * C57BL/6 MGI:4830294
ht2
 		Odf2Gt(XL169)Byg/Odf2+ involves: 129P2/OlaHsd * C57BL/6 MGI:4830291


Genotype
MGI:4830294
ht1
Allelic
Composition		 Odf2Gt(XL169)Byg/Odf2+
Genetic
Background		 chimera involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Odf2Gt(XL169)Byg mutation (0 available); any Odf2 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm flagellum morphology ( J:163862 )
• in more than 50% of sperm from mice with high percentage chimerism
• in less than 5% of sperm from mice with medium to low chimerism
• however, heads are normal
abnormal outer dense fiber morphology ( J:163862 )
• high percentage chimeric mice produce elongating spermatids that lack one or more entire outer dense fibers (ODFs) in their midpiece and principal piece
• elongating spermatids that show thinning of ODFs
abnormal sperm axoneme morphology ( J:163862 )
• some bent tails from mice with high percentage chimerism lack one or more axonemal microtubule doublets compared to in wild-type cells
abnormal sperm midpiece morphology ( J:163862 )
• some spermatid midpieces from mice with high percentage chimerism lack up to 5 entire outer dense fibers compared with wild-type cells
• some midpieces from mice with high percentage chimerism fuse to the principal pieces unlike in wild-type mice
kinked sperm flagellum ( J:163862 )
• more than 50% of sperm have bent tails unlike in wild-type mice

cellular
abnormal sperm flagellum morphology ( J:163862 )
• in more than 50% of sperm from mice with high percentage chimerism
• in less than 5% of sperm from mice with medium to low chimerism
• however, heads are normal
abnormal outer dense fiber morphology ( J:163862 )
• high percentage chimeric mice produce elongating spermatids that lack one or more entire outer dense fibers (ODFs) in their midpiece and principal piece
• elongating spermatids that show thinning of ODFs
abnormal sperm axoneme morphology ( J:163862 )
• some bent tails from mice with high percentage chimerism lack one or more axonemal microtubule doublets compared to in wild-type cells
abnormal sperm midpiece morphology ( J:163862 )
• some spermatid midpieces from mice with high percentage chimerism lack up to 5 entire outer dense fibers compared with wild-type cells
• some midpieces from mice with high percentage chimerism fuse to the principal pieces unlike in wild-type mice
kinked sperm flagellum ( J:163862 )
• more than 50% of sperm have bent tails unlike in wild-type mice




Genotype
MGI:4830291
ht2
Allelic
Composition		 Odf2Gt(XL169)Byg/Odf2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Odf2Gt(XL169)Byg mutation (0 available); any Odf2 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
transmission ratio distortion ( J:163862 )
• only 6 mice are generated from breeding low to medium percent chimeras
male infertility ( J:163862 )
• in 4 of 6 mice
reduced male fertility ( J:163862 )
• in 2 of 6 mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory