Analysis Tools
mortality/aging
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• only one live homozygous embryo is found at E12.5, and none are born
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Allele Symbol Allele Name Allele ID |
AipGt(RRI002)Byg gene trap RRI002, BayGenomics MGI:4128743 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• only one live homozygous embryo is found at E12.5, and none are born
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• among the 88 heterozygous mice, 69 (78.4%) developed one or more pituitary tumors, whereas only 12 (20.7%) of the 58 control littermates displayed this tumor type
• heterozygous mice were prone to develop multiple primary pituitary tumors already at the age of six months, whereas multifocal pituitary tumors were detected among the control mice at much older age groups (1521 months)
• the majority of the heterozygous mice developed GH secreting adenomas (61/69, 88%)
• twenty-one months observation did not reveal excess of any other tumor type in heterozygous mice
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• prolactinomas were relatively common among heterozygous mice
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• macroscopically visible hyperplasia of adrenal glands was detected in a subset of heterozygous mice
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• among the 88 heterozygous mice, 69 (78.4%) developed one or more pituitary tumors, whereas only 12 (20.7%) of the 58 control littermates displayed this tumor type
• heterozygous mice were prone to develop multiple primary pituitary tumors already at the age of six months, whereas multifocal pituitary tumors were detected among the control mice at much older age groups (1521 months)
• the majority of the heterozygous mice developed GH secreting adenomas (61/69, 88%)
• twenty-one months observation did not reveal excess of any other tumor type in heterozygous mice
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• prolactinomas were relatively common among heterozygous mice
|
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• among the 88 heterozygous mice, 69 (78.4%) developed one or more pituitary tumors, whereas only 12 (20.7%) of the 58 control littermates displayed this tumor type
• heterozygous mice were prone to develop multiple primary pituitary tumors already at the age of six months, whereas multifocal pituitary tumors were detected among the control mice at much older age groups (1521 months)
• the majority of the heterozygous mice developed GH secreting adenomas (61/69, 88%)
• twenty-one months observation did not reveal excess of any other tumor type in heterozygous mice
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• prolactinomas were relatively common among heterozygous mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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