Phenotypes associated with this allele

• Allele Symbol: Aip^{Gt(RRI002)Byg}
• Allele Name: gene trap RRI002, BayGenomics
• Allele ID: MGI:4128743
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aip^Gt(RRI002)Byg/Aip^Gt(RRI002)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:4415236
ht2	Aip^Gt(RRI002)Byg/Aip^+	involves: 129P2/OlaHsd * C57BL/6	MGI:4868373

Genotype
MGI:4415236

hm1

• Allelic Composition: Aip^{Gt(RRI002)Byg}/Aip^{Gt(RRI002)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:165349 )

• only one live homozygous embryo is found at E12.5, and none are born

Genotype
MGI:4868373

ht2

• Allelic Composition: Aip^{Gt(RRI002)Byg}/Aip⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

neoplasm

increased pituitary adenoma incidence ( J:165349 )

• among the 88 heterozygous mice, 69 (78.4%) developed one or more pituitary tumors, whereas only 12 (20.7%) of the 58 control littermates displayed this tumor type

• heterozygous mice were prone to develop multiple primary pituitary tumors already at the age of six months, whereas multifocal pituitary tumors were detected among the control mice at much older age groups (1521 months)

• the majority of the heterozygous mice developed GH secreting adenomas (61/69, 88%)

• twenty-one months observation did not reveal excess of any other tumor type in heterozygous mice

increased prolactinoma incidence ( J:165349 )

• prolactinomas were relatively common among heterozygous mice

endocrine/exocrine glands

adrenal gland hyperplasia ( J:165349 )

• macroscopically visible hyperplasia of adrenal glands was detected in a subset of heterozygous mice

increased pituitary adenoma incidence ( J:165349 )

• among the 88 heterozygous mice, 69 (78.4%) developed one or more pituitary tumors, whereas only 12 (20.7%) of the 58 control littermates displayed this tumor type

• heterozygous mice were prone to develop multiple primary pituitary tumors already at the age of six months, whereas multifocal pituitary tumors were detected among the control mice at much older age groups (1521 months)

• the majority of the heterozygous mice developed GH secreting adenomas (61/69, 88%)

• twenty-one months observation did not reveal excess of any other tumor type in heterozygous mice

increased prolactinoma incidence ( J:165349 )

• prolactinomas were relatively common among heterozygous mice

nervous system

increased pituitary adenoma incidence ( J:165349 )

• among the 88 heterozygous mice, 69 (78.4%) developed one or more pituitary tumors, whereas only 12 (20.7%) of the 58 control littermates displayed this tumor type

• heterozygous mice were prone to develop multiple primary pituitary tumors already at the age of six months, whereas multifocal pituitary tumors were detected among the control mice at much older age groups (1521 months)

• the majority of the heterozygous mice developed GH secreting adenomas (61/69, 88%)

• twenty-one months observation did not reveal excess of any other tumor type in heterozygous mice

increased prolactinoma incidence ( J:165349 )

• prolactinomas were relatively common among heterozygous mice