cellular
• in E9.5 embryos
|
• fail to migrate, remaining in neural folds at E10.5
|
• cranial neural crest cells (CNCCs) remain in neural folds at E10.5
|
embryo
• fail to migrate, remaining in neural folds at E10.5
|
• cranial neural crest cells (CNCCs) remain in neural folds at E10.5
|
• mostly failure of anterior (rostral) side, sometimes posterior (caudal)
|
mortality/aging
• most embryos die by E10.5
• no mice are born
|
nervous system
• mostly failure of anterior (rostral) side, sometimes posterior (caudal)
|