About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Specc1lGt(RRH048)Byg
gene trap RRH048, BayGenomics
MGI:4128888
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Specc1lGt(RRH048)Byg/Specc1lGt(RRH048)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:6158522
ht2
 		Specc1lGt(RRH048)Byg/Specc1l+ involves: 129P2/OlaHsd * C57BL/6 MGI:6158524
ht3
 		Specc1lGt(DTM096)Byg/Specc1lGt(RRH048)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:6158520


Genotype
MGI:6158522
hm1
Allelic
Composition		 Specc1lGt(RRH048)Byg/Specc1lGt(RRH048)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Specc1lGt(RRH048)Byg mutation (0 available); any Specc1l mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased apoptosis ( J:250140 )
• in E9.5 embryos
abnormal cranial neural crest cell migration ( J:250140 )
• fail to migrate, remaining in neural folds at E10.5
abnormal neural crest cell delamination ( J:250140 )
• cranial neural crest cells (CNCCs) remain in neural folds at E10.5

embryo
abnormal cranial neural crest cell migration ( J:250140 )
• fail to migrate, remaining in neural folds at E10.5
abnormal neural crest cell delamination ( J:250140 )
• cranial neural crest cells (CNCCs) remain in neural folds at E10.5
abnormal neural tube closure ( J:250140 )
• mostly failure of anterior (rostral) side, sometimes posterior (caudal)

mortality/aging
embryonic lethality, complete penetrance ( J:250140 )
• most embryos die by E10.5
• no mice are born

nervous system
abnormal neural tube closure ( J:250140 )
• mostly failure of anterior (rostral) side, sometimes posterior (caudal)




Genotype
MGI:6158524
ht2
Allelic
Composition		 Specc1lGt(RRH048)Byg/Specc1l+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Specc1lGt(RRH048)Byg mutation (0 available); any Specc1l mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal craniofacial morphology ( J:250140 )
• in some of mice that die perinatally

mortality/aging
prenatal lethality ( J:250140 )
• mice born at lower than expected Mendelian ratio




Genotype
MGI:6158520
ht3
Allelic
Composition		 Specc1lGt(DTM096)Byg/Specc1lGt(RRH048)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Specc1lGt(DTM096)Byg mutation (0 available); any Specc1l mutation (51 available)
Specc1lGt(RRH048)Byg mutation (0 available); any Specc1l mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased apoptosis ( J:250140 )
• in E9.5 embryos
abnormal cranial neural crest cell migration ( J:250140 )
• fail to migrate, remaining in neural folds at E10.5
abnormal neural crest cell delamination ( J:250140 )
• cranial neural crest cells (CNCCs) remain in neural folds at E10.5

embryo
abnormal cranial neural crest cell migration ( J:250140 )
• fail to migrate, remaining in neural folds at E10.5
abnormal neural crest cell delamination ( J:250140 )
• cranial neural crest cells (CNCCs) remain in neural folds at E10.5
abnormal neural tube closure ( J:250140 )
• mostly failure of anterior (rostral) side, sometimes posterior (caudal)

mortality/aging
embryonic lethality, complete penetrance ( J:250140 )
• most embryos die by E10.5
• no mice are born

nervous system
abnormal neural tube closure ( J:250140 )
• mostly failure of anterior (rostral) side, sometimes posterior (caudal)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory