Analysis Tools
behavior/neurological
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• in a rotarod assay, adult males show higher voluntary motor activity and enhanced motor learning capacity during training, concomitant with an increase in dendritic GRID2 protein expression in parallel fiber dendrites of cerebellar Purkinje cells
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• in a rotarod assay, both adult males and females exhibit a lower latency to fall than age- and sex-matched wild-type controls on day 1
• on day 2, males, but not females, improve their test performance relative to age-matched wild-type males, although general performance is still lower
• adult trained mice show an upregulation of Cbln1 (cerebellin 1 precursor protein) and Grid2 (glutamate receptor, ionotropic, delta 2) mRNA during behavioral testing
• however, naive mice show no apparent changes in the expression of Cbln1 and Grid2 mRNAs
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nervous system
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• adult males exhibit enhanced Purkinje cell synaptogenesis after stimulation of motor activity by voluntary wheel running, as shown by a 50% increase in GRID2 expression and elevated GRID2/SLC17A7 colocalization in the stratum moleculare
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• enhanced motor learning skills during repeated training concomitant with an increased GRID2 expression suggest improved synaptic transmission in the cerebellum
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