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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
LyarGt(RRG292)Byg
gene trap RRG292, BayGenomics
MGI:4128951
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
LyarGt(RRG292)Byg/LyarGt(RRG292)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:6191735
ht2
LyarGt(RRG292)Byg/Lyar+ involves: 129P2/OlaHsd * C57BL/6 MGI:6191736
cx3
LyarGt(RRG292)Byg/LyarGt(RRG292)Byg
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:6191737
cx4
LyarGt(RRG292)Byg/Lyar+
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:6191738


Genotype
MGI:6191735
hm1
Allelic
Composition
LyarGt(RRG292)Byg/LyarGt(RRG292)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
LyarGt(RRG292)Byg mutation (0 available); any Lyar mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• in primary mouse embryonic fibroblasts




Genotype
MGI:6191736
ht2
Allelic
Composition
LyarGt(RRG292)Byg/Lyar+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
LyarGt(RRG292)Byg mutation (0 available); any Lyar mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• intermediate in primary mouse embryonic fibroblasts




Genotype
MGI:6191737
cx3
Allelic
Composition
LyarGt(RRG292)Byg/LyarGt(RRG292)Byg
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
LyarGt(RRG292)Byg mutation (0 available); any Lyar mutation (30 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the only two mice produced from breeding heterozygotes die by 8 months from thymic lymphoma
• fewer than expected mice were recovered, motsly affecting female mice

nervous system
• in 11 of 18 mice at E16.5 to E18.5 mostly in female mice

neoplasm
• as in Trp53tm1Tyj homozygotes

limbs/digits/tail
• in some mice

endocrine/exocrine glands
• as in Trp53tm1Tyj homozygotes

hematopoietic system
• as in Trp53tm1Tyj homozygotes

immune system
• as in Trp53tm1Tyj homozygotes




Genotype
MGI:6191738
cx4
Allelic
Composition
LyarGt(RRG292)Byg/Lyar+
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
LyarGt(RRG292)Byg mutation (0 available); any Lyar mutation (30 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice were recovered

embryo
• in 1 of 27 mice

nervous system
• in 1 of 27 mice
• in 7 of 27 mice at E16.5 to E18.5 mostly in female mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory