Phenotypes associated with this allele

• Allele Symbol: Cdk5rap2^{Gt(RRF465)Byg}
• Allele Name: gene trap RRF465, BayGenomics
• Allele ID: MGI:4129121
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk5rap2^Gt(RRF465)Byg/Cdk5rap2^Gt(RRF465)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:4830308

Genotype
MGI:4830308

hm1

• Allelic Composition: Cdk5rap2^{Gt(RRF465)Byg}/Cdk5rap2^{Gt(RRF465)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

male infertility ( J:163849 )

♂ • in 2 of 6 mice

cellular

abnormal microtubule organizing center morphology ( J:163849 )

• MEFs exhibit a 4-fold increased in the occurrence of 3 centrioles and a 5-fold increase in cells with more than 4 centrioles compared with wild-type MEFs

• brain cells from E14.5 embryos exhibit increased centriole numbers compared with cells from wild-type mice

• centrioles lose engagement and cohesion compared to in wild-type cells

abnormal centrosome morphology ( J:163849 )

• centrosomes are disrupted in mouse embryonic fibroblasts (MEFs) compared to in wild-type cells

abnormal pericentriolar material morphology ( J:163849 )

• pericentriolar material architecture is disrupted in MEFs compared to in wild-type cells

abnormal cell nucleus morphology ( J:163849 )

• nuclei are enlarged 3-fold in MEFs compared to in wild-type cells

• however, DNA content is normal

abnormal plasma membrane morphology ( J:163849 )

• 7-fold more mouse embryonic fibroblasts exhibit an increase in primary cilia compared with wild-type cells

abnormal mitosis ( J:163849 )

• mouse embryonic fibroblasts exhibit prolonged anaphase compared with wild-type cells

abnormal mitotic spindle morphology ( J:163849 )

• more mouse embryonic fibroblasts exhibit multipolar spindles compared with wild-type cells

early cellular replicative senescence ( J:163849 )

• in mouse embryonic fibroblasts without an alteration in cell cycle