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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ccar2Gt(XN876)Byg
gene trap XN876, BayGenomics
MGI:4129528
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ccar2Gt(XN876)Byg/Ccar2Gt(XN876)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:4429496


Genotype
MGI:4429496
hm1
Allelic
Composition
Ccar2Gt(XN876)Byg/Ccar2Gt(XN876)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccar2Gt(XN876)Byg mutation (0 available); any Ccar2 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Ccar2Gt(XN876)Byg/Ccar2Gt(XN876)Byg mice are protected against high fat diet-induced liver steatosis

liver/biliary system
• significantly lower lipid content in the liver of 20 week old mice on a high calorie high fat diet however, no significant difference in food consumption or weight gain is detected in mice on a high calorie high fat diet
• display protection from high calorie high fat diet induced liver damage and inflammation
• decreased IL6 and TNF alpha levels in livers of high fat diet fed mice compared to diet matched wild-type controls

immune system
• Kupffer cells, treated with LPS, release less TNF-alpha into media





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory