Phenotypes associated with this allele

• Allele Symbol: Nlk^{Gt(RRJ297)Byg}
• Allele Name: gene trap RRJ297, BayGenomics
• Allele ID: MGI:4130034
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Nlk^Gt(RRJ297)Byg/Nlk^+	B6.129P2-Nlk^Gt(RRJ297)Byg	MGI:5521730
ht2	Nlk^Gt(RRJ297)Byg/Nlk^Gt(XN619)Byg	129S6.129P2-Nlk^Gt(RRJ297)Byg/Nlk^Gt(XN619)Byg	MGI:5521738
ht3	Nlk^Gt(RRJ297)Byg/Nlk^Gt(XN619)Byg	B6.129P2-Nlk^Gt(RRJ297)Byg/Nlk^Gt(XN619)Byg	MGI:5521735
cx4	Atxn1^tm1Hzo/Atxn1^+ Nlk^Gt(RRJ297)Byg/Nlk^+	B6.129-Nlk^Gt(RRJ297)Byg Atxn1^tm1Hzo	MGI:5521733

Genotype
MGI:5521730

ht1

• Allelic Composition: Nlk^{Gt(RRJ297)Byg}/Nlk⁺
• Genetic Background: B6.129P2-Nlk^{Gt(RRJ297)Byg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:198661 )

• on a rotarod

• however, mice exhibit normal performance on a dowel rod walking test

Genotype
MGI:5521738

ht2

• Allelic Composition: Nlk^{Gt(RRJ297)Byg}/Nlk^Gt(XN619)Byg
• Genetic Background: 129S6.129P2-Nlk^{Gt(RRJ297)Byg}/Nlk^Gt(XN619)Byg

mortality/aging

premature death ( J:198661 )

• Background Sensitivity: mice on a congenic 129S6 background survive up to several months of age unlike mice on a congenic C57BL/6 background that die at birth

behavior/neurological

abnormal behavior ( J:198661 )

• various unspecified neurological and non-neurological abnormalities

Genotype
MGI:5521735

ht3

• Allelic Composition: Nlk^{Gt(RRJ297)Byg}/Nlk^Gt(XN619)Byg
• Genetic Background: B6.129P2-Nlk^{Gt(RRJ297)Byg}/Nlk^Gt(XN619)Byg

mortality/aging

neonatal lethality, complete penetrance ( J:198661 )

• Background Sensitivity: mice on a congenic C57BL/6 background die at birth unlike mice on a congenic 129S6 background that survive several months

Genotype
MGI:5521733

cx4

• Allelic Composition: Atxn1^tm1Hzo/Atxn1⁺; Nlk^{Gt(RRJ297)Byg}/Nlk⁺
• Genetic Background: B6.129-Nlk^{Gt(RRJ297)Byg} Atxn1^tm1Hzo

behavior/neurological

behavior/neurological phenotype ( J:198661 )

N • unlike Atxn1^tm1Hzo heterozygotes, mice exhibit normal performance on a dowel rod walking test

nervous system

nervous system phenotype ( J:198661 )

N • mice exhibit improved complexity of fine dendritic arbors and Purkinje cell soma at 38 to 39 weeks of age and molecular layer thickness compared with Atxn1^tm1Hzo heterozygotes