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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		MthfsGt(RRK291)Byg
gene trap RRK291, BayGenomics
MGI:4130253
Summary 3 genotypes


Genotype
MGI:5430743
hm1
Allelic
Composition		 MthfsGt(RRK291)Byg/MthfsGt(RRK291)Byg
Genetic
Background		 B6.129P2-MthfsGt(RRK291)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MthfsGt(RRK291)Byg mutation (0 available); any Mthfs mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:185874 )
• die before E9.5, even with maternal dietary purine supplementation




Genotype
MGI:5430744
ht2
Allelic
Composition		 MthfsGt(RRK291)Byg/Mthfs+
Genetic
Background		 B6.129P2-MthfsGt(RRK291)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MthfsGt(RRK291)Byg mutation (0 available); any Mthfs mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal folic acid level ( J:185874 )
• decreased folate levels in the plasma in mice on a normal chow diet compared to diet matched controls
abnormal enzyme/coenzyme activity ( J:185874 )
• decrease in de novo purine synthesis

behavior/neurological
behavior/neurological phenotype ( J:185874 )
N
• no difference in food intake

growth/size/body
growth/size/body region phenotype ( J:185874 )
N
• no difference in weight gain




Genotype
MGI:5430745
cx3
Allelic
Composition		 ApcMin/Apc+
MthfsGt(RRK291)Byg/Mthfs+
Genetic
Background		 B6.Cg-MthfsGt(RRK291)Byg ApcMin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (156 available)
MthfsGt(RRK291)Byg mutation (0 available); any Mthfs mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:185874 )
N
• small intestine and colon tumor incidence is similar to mice heterozygous for ApcMin alone




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory