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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ropn1Gt(OST21705)Lex
gene trap OST21705, Lexicon Genetics
MGI:4144733
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ropn1Gt(OST21705)Lex/Ropn1Gt(OST21705)Lex involves: 129S5/SvEvBrd MGI:5552711
cx2
 		Ropn1Gt(OST21705)Lex/Ropn1Gt(OST21705)Lex
Ropn1lGt(OST20298)Lex/Ropn1lGt(OST20298)Lex 		involves: 129S5/SvEvBrd MGI:5552713


Genotype
MGI:5552711
hm1
Allelic
Composition		 Ropn1Gt(OST21705)Lex/Ropn1Gt(OST21705)Lex
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ropn1Gt(OST21705)Lex mutation (2 available); any Ropn1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
asthenozoospermia ( J:206788 )
• slightly less vigorous sperm motility to nearly immotile compared with wild-type sperm
decreased litter size ( J:206788 )
• from male mice
reduced male fertility ( J:206788 )
• fewer litters with fewer pups per litter

respiratory system
respiratory system phenotype ( J:206788 )
N
• mice exhibit normal respiratory cilia morphology and physiology

cellular
asthenozoospermia ( J:206788 )
• slightly less vigorous sperm motility to nearly immotile compared with wild-type sperm




Genotype
MGI:5552713
cx2
Allelic
Composition		 Ropn1Gt(OST21705)Lex/Ropn1Gt(OST21705)Lex
Ropn1lGt(OST20298)Lex/Ropn1lGt(OST20298)Lex
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ropn1Gt(OST21705)Lex mutation (2 available); any Ropn1 mutation (10 available)
Ropn1lGt(OST20298)Lex mutation (2 available); any Ropn1l mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
immotile sperm ( J:206788 )
• completely immotile
male infertility ( J:206788 )
• despite confirmed mating

cellular
immotile sperm ( J:206788 )
• completely immotile

respiratory system
respiratory system phenotype ( J:206788 )
N
• mice exhibit normal respiratory cilia morphology and physiology




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory