About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ropn1Gt(OST21705)Lex
gene trap OST21705, Lexicon Genetics
MGI:4144733
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ropn1Gt(OST21705)Lex/Ropn1Gt(OST21705)Lex involves: 129S5/SvEvBrd MGI:5552711
cx2
 		Ropn1Gt(OST21705)Lex/Ropn1Gt(OST21705)Lex
Ropn1lGt(OST20298)Lex/Ropn1lGt(OST20298)Lex 		involves: 129S5/SvEvBrd MGI:5552713


Genotype
MGI:5552711
hm1
Allelic
Composition		 Ropn1Gt(OST21705)Lex/Ropn1Gt(OST21705)Lex
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ropn1Gt(OST21705)Lex mutation (2 available); any Ropn1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
asthenozoospermia ( J:206788 )
• slightly less vigorous sperm motility to nearly immotile compared with wild-type sperm
decreased litter size ( J:206788 )
• from male mice
reduced male fertility ( J:206788 )
• fewer litters with fewer pups per litter

respiratory system
respiratory system phenotype ( J:206788 )
N
• mice exhibit normal respiratory cilia morphology and physiology

cellular
asthenozoospermia ( J:206788 )
• slightly less vigorous sperm motility to nearly immotile compared with wild-type sperm




Genotype
MGI:5552713
cx2
Allelic
Composition		 Ropn1Gt(OST21705)Lex/Ropn1Gt(OST21705)Lex
Ropn1lGt(OST20298)Lex/Ropn1lGt(OST20298)Lex
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ropn1Gt(OST21705)Lex mutation (2 available); any Ropn1 mutation (10 available)
Ropn1lGt(OST20298)Lex mutation (2 available); any Ropn1l mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
immotile sperm ( J:206788 )
• completely immotile
male infertility ( J:206788 )
• despite confirmed mating

cellular
immotile sperm ( J:206788 )
• completely immotile

respiratory system
respiratory system phenotype ( J:206788 )
N
• mice exhibit normal respiratory cilia morphology and physiology




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory