Phenotypes associated with this allele

• Allele Symbol: Rras2^{Gt(OST47398)Lex}
• Allele Name: gene trap OST47398, Lexicon Genetics
• Allele ID: MGI:4160490
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rras2^Gt(OST47398)Lex/Rras2^Gt(OST47398)Lex	B6;129S5-Rras2^Gt(OST47398)Lex/Ieg	MGI:5428701

Genotype
MGI:5428701

hm1

• Allelic Composition: Rras2^{Gt(OST47398)Lex}/Rras2^{Gt(OST47398)Lex}
• Genetic Background: B6;129S5-Rras2^{Gt(OST47398)Lex}/Ieg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:82809 )

♂ • male homozygotes have higher mean total body fat as compared to the gender-matched wild-type littermates

cardiovascular system

abnormal retina vasculature morphology ( J:82809 )

• ophthalmic observations found reduced mean artery-to-vein ratio in the homozygous mutant mice as compared to wild-type littermates

growth/size/body

increased body size ( J:82809 )

♂ • male homozygotes have a higher mean total tissue mass compared to the gender-matched wild-type littermates

vision/eye

abnormal retina vasculature morphology ( J:82809 )

• ophthalmic observations found reduced mean artery-to-vein ratio in the homozygous mutant mice as compared to wild-type littermates

thin retina outer nuclear layer ( J:82809 )

• reduction in thickness of external nuclear layer

abnormal retina outer plexiform layer morphology ( J:82809 )

• vacuolization of external plexiorm layer

abnormal retina photoreceptor layer morphology ( J:82809 )

• reduction in thickness of photoreceptor layer

• vacuolization of photoreceptor layer

retina degeneration ( J:82809 )

• homozygotes showed signs of retinal degeneration