Phenotypes associated with this allele

• Allele Symbol: Lrba^{Gt(OST69142)Lex}
• Allele Name: gene trap OST69142, Lexicon Genetics
• Allele ID: MGI:4173110
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrba^Gt(OST69142)Lex/Lrba^Gt(OST69142)Lex	involves: 129 * 129S5/SvEvBrd	MGI:5811657

Genotype
MGI:5811657

hm1

• Allelic Composition: Lrba^{Gt(OST69142)Lex}/Lrba^{Gt(OST69142)Lex}
• Genetic Background: involves: 129 * 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased regulatory T cell number ( J:237187 )

• increased Treg population in small intestine

increased myeloid cell number ( J:237187 )

• myeloid derived suppressor cell (MDSC) (Mac1+ Gr1+) population is increased in spleen and mesenteric lymph nodes

abnormal NK cell physiology ( J:237187 )

• stimulated natural killer cells exhibit impaired phosphorylation of the ERK1/2 and AKT signaling molecules

impaired natural killer cell mediated cytotoxicity ( J:237187 )

• cytolytic response to a target cell as measured by granzyme B secretion is defective in an vitro NK cell assay

immune system

increased regulatory T cell number ( J:237187 )

• increased Treg population in small intestine

abnormal NK cell physiology ( J:237187 )

• stimulated natural killer cells exhibit impaired phosphorylation of the ERK1/2 and AKT signaling molecules

impaired natural killer cell mediated cytotoxicity ( J:237187 )

• cytolytic response to a target cell as measured by granzyme B secretion is defective in an vitro NK cell assay

decreased susceptibility to graft versus host disease ( J:237187 )

• mutant hosts survive in a lethal GvHD challenge

increased length of allograft survival ( J:237187 )

• rejection of bone marrow grafts from MHC Class I mismatched donors is impaired

• mutant hosts have a higher number of allogeneic donors cells relative to wild-type

• engraftment of human bone marrow cells is improved as compared to engraftment in wild-type