Analysis Tools
adipose tissue
mortality/aging
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• fewer than expected mice at 2 weeks of age
• however, survival after 2 weeks is normal
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hematopoietic system
craniofacial
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• in all molar of aged mice
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• shorter, thinner and more irregular in shape than in wild-type mice
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• in aged mice with irregular thickened bands of collagen
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• irregular aggregation of dysplastic cementum covering outer surfaces of molar roots
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• all mice exhibit thin mantle dentin on both molar and incisor (lingual and labial quadrant) teeth with disorganized and atubular underlying dentin compared with wild-type mice
• however, lateral and medial quadrant incisor dentin is normal
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• entrapped at the lingual and labial quadrants of incisors
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• of molars; widespread in aged mice
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• suppurative inflammation with periapical abscesses in older mice
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limbs/digits/tail
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• in female and male mice at 16 weeks without further increase through one year age
• with increased bone area, polar moment of inertia and bone strength
• however, trabecular bone volume to trabecular volume in vertebrae and total bone area are normal
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renal/urinary system
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• in mice with one kidney
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• either left or right in 23 of 89 mice
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immune system
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• mild
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• mild to moderate in young mice restricted to teeth and roots with necrotic pulp
• in all molar teeth of older mice
• suppurative inflammation with periapical abscesses in older mice
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growth/size/body
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• in all molar of aged mice
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• shorter, thinner and more irregular in shape than in wild-type mice
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• in aged mice with irregular thickened bands of collagen
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• irregular aggregation of dysplastic cementum covering outer surfaces of molar roots
|
|
• all mice exhibit thin mantle dentin on both molar and incisor (lingual and labial quadrant) teeth with disorganized and atubular underlying dentin compared with wild-type mice
• however, lateral and medial quadrant incisor dentin is normal
|
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• entrapped at the lingual and labial quadrants of incisors
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• of molars; widespread in aged mice
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• suppurative inflammation with periapical abscesses in older mice
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• with increasing age
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• slightly
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• in mice with one kidney
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skeleton
| N |
• mice exhibit normal femur length and LV5 trabecular bone volume to trabecular volume
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• in all molar of aged mice
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• shorter, thinner and more irregular in shape than in wild-type mice
|
|
• in aged mice with irregular thickened bands of collagen
|
|
• irregular aggregation of dysplastic cementum covering outer surfaces of molar roots
|
|
• all mice exhibit thin mantle dentin on both molar and incisor (lingual and labial quadrant) teeth with disorganized and atubular underlying dentin compared with wild-type mice
• however, lateral and medial quadrant incisor dentin is normal
|
|
• entrapped at the lingual and labial quadrants of incisors
|
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• of molars; widespread in aged mice
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• suppurative inflammation with periapical abscesses in older mice
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• in female and male
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• of femur, tibia, humerus, radius, pelvis and femoral neck of female and male mice
• in mice following post-pubertal ovariectomy-induced bone loss
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• in female and male mice at 16 weeks without further increase through one year age
• with increased bone area, polar moment of inertia and bone strength
• however, trabecular bone volume to trabecular volume in vertebrae and total bone area are normal
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