Phenotypes associated with this allele

• Allele Symbol: Amt^{Gt(OST181110)Lex}
• Allele Name: gene trap OST181110, Lexicon Genetics
• Allele ID: MGI:4218349
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Amt^Gt(OST181110)Lex/Amt^Gt(OST181110)Lex	B6.129S5-Amt^Gt(OST181110)Lex	MGI:5312930

Genotype
MGI:5312930

hm1

• Allelic Composition: Amt^{Gt(OST181110)Lex}/Amt^{Gt(OST181110)Lex}
• Genetic Background: B6.129S5-Amt^{Gt(OST181110)Lex}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality ( J:181568 )

• no homozygotes are found postnatally

nervous system

abnormal neural tube morphology ( J:181568 )

• neural tube defects in 87% of E17.5 embryos

• maternal treatment with methionine or methionine and thymidine-1-phosphate has a protective effect on embryos

incomplete rostral neuropore closure ( J:181568 )

• exencephaly in 82% of E16.5 embryos

• cranial neural folds fail to close

craniorachischisis ( J:181568 )

• in 5% of E17.5 embryos

• neural tube is open from the level of the mid- or hindbrain through the spinal region

exencephaly ( J:181568 )

• in 82% of E17.5 embryos

• neural folds fail to close

embryo

abnormal neural tube morphology ( J:181568 )

• neural tube defects in 87% of E17.5 embryos

• maternal treatment with methionine or methionine and thymidine-1-phosphate has a protective effect on embryos

incomplete rostral neuropore closure ( J:181568 )

• exencephaly in 82% of E16.5 embryos

• cranial neural folds fail to close

craniorachischisis ( J:181568 )

• in 5% of E17.5 embryos

• neural tube is open from the level of the mid- or hindbrain through the spinal region