Phenotypes associated with this allele

• Allele Symbol: Plagl1^{Gt(OST181461)Lex}
• Allele Name: gene trap OST181461, Lexicon Genetics
• Allele ID: MGI:4218514
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plagl1^Gt(OST181461)Lex/Plagl1^Gt(OST181461)Lex	involves: 129S5/SvEvBrd	MGI:4949737
ht2	Plagl1^Gt(OST181461)Lex/Plagl1^+	involves: 129S5/SvEvBrd	MGI:4949736

Genotype
MGI:4949737

hm1

• Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1^{Gt(OST181461)Lex}
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:171037 )

• reduced survival to age 90 days

postnatal lethality, incomplete penetrance ( J:171037 )

• further mortality evident from birth to day 5 after birth

prenatal lethality, incomplete penetrance ( J:171037 )

• embryos with defective neural tubes (about 9%) do not survive to E17.5

growth/size/body

decreased birth weight ( J:171037 )

• neonatal weight loss

nervous system

abnormal neural tube closure ( J:171037 )

• defective neural tube closure at E10.5 in 9% of embryos

• embryos with defective neural tubes do not survive to E17.5

cardiovascular system

abnormal heart morphology ( J:171037 )

• increased numbers of apoptotic cells in the adult heart

• heart morphology is normal in adults

atrial septal defect ( J:171037 )

• atrial septal defect at E15.5 in 42% of embryos

muscular ventricular septal defect ( J:171037 )

• fenestration at E15.5 in 23% of embryos

• ventricular wall also thin

integument

wrinkled skin ( J:171037 )

limbs/digits/tail

curly tail ( J:171037 )

embryo

abnormal neural tube closure ( J:171037 )

• defective neural tube closure at E10.5 in 9% of embryos

• embryos with defective neural tubes do not survive to E17.5

Genotype
MGI:4949736

ht2

• Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1⁺
• Genetic Background: involves: 129S5/SvEvBrd

cellular

paternal imprinting ( J:171037 )

• heterozygous phenotype is only expressed when inheritance if from the father

mortality/aging

decreased survivor rate ( J:171037 )

• reduced survival to age 90 days when the allele is inherited paternally

postnatal lethality ( J:171037 )

• further mortality evident from birth to day 5 after birth when the allele is inherited paternally

prenatal lethality ( J:171037 )

• embryos with defective neural tubes (about 9%) do not survive to E17.5 when the allele is inherited paternally

growth/size/body

decreased birth weight ( J:171037 )

• neonatal weight loss when the allele is inherited paternally

nervous system

abnormal neural tube closure ( J:171037 )

• defective neural tube closure at E10.5 in 9% of embryos when the allele is inherited paternally

• embryos with defective neural tubes do not survive to E17.5 when the allele is inherited paternally

cardiovascular system

abnormal heart morphology ( J:171037 )

• increased numbers of apoptotic cells in the adult heart when the allele is inherited paternally

• heart morphology is normal in adults when the allele is inherited paternally

atrial septal defect ( J:171037 )

• atrial septal defect at E15.5 in 42% of embryos when the allele is inherited paternally

muscular ventricular septal defect ( J:171037 )

• fenestration at E15.5 in 23% of embryos when the allele is inherited paternally

• ventricular wall also thin when the allele is inherited paternally

limbs/digits/tail

curly tail ( J:171037 )

• when the allele is inherited paternally

integument

wrinkled skin ( J:171037 )

• when the allele is inherited paternally

embryo

abnormal neural tube closure ( J:171037 )

• defective neural tube closure at E10.5 in 9% of embryos when the allele is inherited paternally

• embryos with defective neural tubes do not survive to E17.5 when the allele is inherited paternally