Phenotypes associated with this allele

• Allele Symbol: Itfg2^{Gt(OST215121)Lex}
• Allele Name: gene trap OST215121, Lexicon Genetics
• Allele ID: MGI:4235940
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itfg2^Gt(OST215121)Lex/Itfg2^Gt(OST215121)Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:5552961
cx2	Fas^lpr/Fas^lpr Itfg2^Gt(OST215121)Lex/Itfg2^Gt(OST215121)Lex	involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp	MGI:5552962

Genotype
MGI:5552961

hm1

• Allelic Composition: Itfg2^{Gt(OST215121)Lex}/Itfg2^{Gt(OST215121)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:205951 )

N • T and B cell development exhibit normal development

N • mice exhibit normal numbers of neutrophils, monocytes, NK cells, red blood cells and platelets

N • mice exhibit normal development of experimental autoimmune encephalomyelitis

spleen hyperplasia ( J:205951 )

• due to increased B cells

increased B cell number ( J:205951 )

• in the spleen

decreased lymphocyte cell number ( J:205951 )

decreased B cell number ( J:205951 )

• in the periphery

decreased T follicular helper cell number ( J:205951 )

• after immunization with NP-CGG

decreased spleen germinal center number ( J:205951 )

• with fewer B cells after immunization with NP-CGG

• however, wild-type bone marrows transferred into irradiated recipient mice rescues germinal center development

abnormal B cell activation ( J:205951 )

• after immunization with NP-CGG, mice exhibit increased extrafollicular B cell differentiation compared with wild-type mice

abnormal splenocyte physiology ( J:205951 )

• decreased migration in response to chemokines

abnormal humoral immune response ( J:205951 )

• reduced antibody secreting cells after immunization with NP-CGG

decreased IgE level ( J:205951 )

• in unimmunized mice

decreased IgG1 level ( J:205951 )

• prior to and after immunization with NP-CGG

decreased IgG2a level ( J:205951 )

• prior to and after immunization with NP-CGG

decreased IgG2b level ( J:205951 )

• prior to and after immunization with NP-CGG

decreased IgG3 level ( J:205951 )

• in unimmunized mice

hematopoietic system

spleen hyperplasia ( J:205951 )

• due to increased B cells

increased B cell number ( J:205951 )

• in the spleen

decreased lymphocyte cell number ( J:205951 )

decreased B cell number ( J:205951 )

• in the periphery

decreased T follicular helper cell number ( J:205951 )

• after immunization with NP-CGG

decreased spleen germinal center number ( J:205951 )

• with fewer B cells after immunization with NP-CGG

• however, wild-type bone marrows transferred into irradiated recipient mice rescues germinal center development

abnormal B cell activation ( J:205951 )

• after immunization with NP-CGG, mice exhibit increased extrafollicular B cell differentiation compared with wild-type mice

decreased IgE level ( J:205951 )

• in unimmunized mice

decreased IgG1 level ( J:205951 )

• prior to and after immunization with NP-CGG

decreased IgG2a level ( J:205951 )

• prior to and after immunization with NP-CGG

decreased IgG2b level ( J:205951 )

• prior to and after immunization with NP-CGG

decreased IgG3 level ( J:205951 )

• in unimmunized mice

abnormal splenocyte physiology ( J:205951 )

• decreased migration in response to chemokines

growth/size/body

spleen hyperplasia ( J:205951 )

• due to increased B cells

Genotype
MGI:5552962

cx2

• Allelic Composition: Fas^lpr/Fas^lpr; Itfg2^{Gt(OST215121)Lex}/Itfg2^{Gt(OST215121)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

immune system

enlarged spleen ( J:205951 )

• worse than in Fas^lpr homozygotes

increased double-negative T cell number ( J:205951 )

• increased faster in the blood and to a higher proportion than in Fas^lpr homozygotes

decreased B cell number ( J:205951 )

• decreased circulating B cells for the first 13 weeks of age compared with Fas^lpr homozygotes

increased IgG2a level ( J:205951 )

• from 19 weeks compared with Fas^lpr homozygotes

increased IgM level ( J:205951 )

• from 19 weeks compared with Fas^lpr homozygotes

enlarged lymph nodes ( J:205951 )

• worse than in Fas^lpr homozygotes

increased susceptibility to systemic lupus erythematosus ( J:205951 )

• more severe autoimmune disease development with inflammatory cell infiltration of the kidney and hypertrophy in the lymphoid organs compared with Fas^lpr homozygotes

increased anti-nuclear antigen antibody level ( J:205951 )

• compared with Fas^lpr homozygotes

increased anti-double stranded DNA antibody level ( J:205951 )

• compared with Fas^lpr homozygotes

homeostasis/metabolism

increased urine protein level ( J:205951 )

• compared with Fas^lpr homozygotes

renal/urinary system

increased urine protein level ( J:205951 )

• compared with Fas^lpr homozygotes

hematopoietic system

enlarged spleen ( J:205951 )

• worse than in Fas^lpr homozygotes

increased double-negative T cell number ( J:205951 )

• increased faster in the blood and to a higher proportion than in Fas^lpr homozygotes

decreased B cell number ( J:205951 )

• decreased circulating B cells for the first 13 weeks of age compared with Fas^lpr homozygotes

increased IgG2a level ( J:205951 )

• from 19 weeks compared with Fas^lpr homozygotes

increased IgM level ( J:205951 )

• from 19 weeks compared with Fas^lpr homozygotes

growth/size/body

enlarged spleen ( J:205951 )

• worse than in Fas^lpr homozygotes