Analysis Tools
reproductive system
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• female mice fail to successfully carry a litter unlike wild-type mice
• however, female mice fed regular chow with 1% ascorbate successfully breed and wean normal litters
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skeleton
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• cell masses of developmentally arrested immature osteoblasts accumulate in pregnant and unmated female mice, castrated male mice, and mice fed regular chow lacking ascorbate unlike in wild-type mice
• however, diets containing ascorbate prevents proliferative response
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• castrated mice fail to exhibit an increase in osteoblast parameters unlike in wild-type mice
• however, diets containing ascorbate and pycnogenol or resveratrol result in elevated osteoblast parameters comparable to those observed in castrated wild-type mice
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• however, diets with ascorbate preserves nasal turbinate organization
• mice exhibit a disappearance of trabecular bone from the nasal turbinates, which is replaced by proliferating cell masses, unlike wild-type mice
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• castrated mice exhibit increased osteoclast parameters compared with wild-type mice
• however, diets containing ascorbate and pycnogenol result in elevated osteoblast parameters comparable to those observed in castrated wild-type mice
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• castrated mice exhibit increased osteoclast parameters compared with wild-type mice
• however, diets containing ascorbate and pycnogenol result in elevated osteoblast parameters comparable to those observed in castrated wild-type mice
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• castrated male mice exhibit a greater loss of bone compared with wild-type mice
• however, diets containing ascorbate, pyncognerol, or resveratrol restores trabeculae thickness to levels observed in castrated wild-type mice
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• in pregnant female mice
• however, female mice fed regular chow with 1% ascorbate prevents bone changes
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• castrated mice fail to exhibit an increase in osteoblast parameters unlike in wild-type mice
• however, diets ascorbate and pycnogenol or resveratrol result in elevated osteoblast parameters comparable to those observed in castrated wild-type mice
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• pregnant female mice exhibit severe loss of trabecular bone at the growth plates with fractures and callus formation unlike in wild-type mice
• unmated female mice exhibit proliferation of dysplastic mesenchymal cell masses in the long bones, vertebrae, and nasal turbinates compared with wild-type mice
• castrated male mice exhibit resorption of trabecular bones and dysplastic cell masses compared with wild-type mice
• however, diets containing ascorbate preserves normal bone organization
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• in castrated mice
• however, diets containing ascorbate, pyncognerol, or resveratrol restores trabeculae thickness to levels observed in castrated wild-type mice
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• in castrated mice
• however, diets containing ascorbate, pyncognerol, or resveratrol restores trabeculae thickness to levels observed in castrated wild-type mice
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osteoporosis
(
J:164548
)
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• pregnant female mice exhibit severe osteoporosis compared with wild-type mice
• mice exhibit mild age-related osteroperosis, preferentially affecting female mice, compared with wild-type mice
• however, diets containing ascorbate prevents abnormal bone loss
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• in pregnant female mice
• however, female mice fed regular chow with 1% ascorbate prevents bone changes
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homeostasis/metabolism
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• male mice exhibit a 3.5-fold increase in urinary glucuronate excretion compared with wild-type mice
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• male mice exhibit a decrease in liver and kidney ascorbate levels compared with wild-type mice
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renal/urinary system
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• male mice exhibit a 3.5-fold increase in urinary glucuronate excretion compared with wild-type mice
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respiratory system
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• mice exhibit a disappearance of trabecular bone from the nasal turbinates, which is replaced by proliferating cell masses, unlike wild-type mice
• however, diets with ascorbate preserves nasal turbinate organization
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craniofacial
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• mice exhibit a disappearance of trabecular bone from the nasal turbinates, which is replaced by proliferating cell masses, unlike wild-type mice
• however, diets with ascorbate preserves nasal turbinate organization
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hematopoietic system
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• castrated mice exhibit increased osteoclast parameters compared with wild-type mice
• however, diets containing ascorbate and pycnogenol result in elevated osteoblast parameters comparable to those observed in castrated wild-type mice
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• castrated mice exhibit increased osteoclast parameters compared with wild-type mice
• however, diets containing ascorbate and pycnogenol result in elevated osteoblast parameters comparable to those observed in castrated wild-type mice
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immune system
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• castrated mice exhibit increased osteoclast parameters compared with wild-type mice
• however, diets containing ascorbate and pycnogenol result in elevated osteoblast parameters comparable to those observed in castrated wild-type mice
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• castrated mice exhibit increased osteoclast parameters compared with wild-type mice
• however, diets containing ascorbate and pycnogenol result in elevated osteoblast parameters comparable to those observed in castrated wild-type mice
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cellular
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• cell masses of developmentally arrested immature osteoblasts accumulate in pregnant and unmated female mice, castrated male mice, and mice fed regular chow lacking ascorbate unlike in wild-type mice
• however, diets containing ascorbate prevents proliferative response
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• castrated mice fail to exhibit an increase in osteoblast parameters unlike in wild-type mice
• however, diets containing ascorbate and pycnogenol or resveratrol result in elevated osteoblast parameters comparable to those observed in castrated wild-type mice
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growth/size/body
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• mice exhibit a disappearance of trabecular bone from the nasal turbinates, which is replaced by proliferating cell masses, unlike wild-type mice
• however, diets with ascorbate preserves nasal turbinate organization
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