All Phenotypes Slc5a1<Gt(OST315271)Lex> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc5a1^{Gt(OST315271)Lex}/Slc5a1^{Gt(OST315271)Lex}	involves: 129S5/SvEvBrd * C57BL/6J	MGI:5487581
cx2	Slc5a1^{Gt(OST315271)Lex}/Slc5a1^{Gt(OST315271)Lex} Slc5a2^tm1Lex/Slc5a2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:5487583

Allelic Composition	Slc5a1^{Gt(OST315271)Lex}/Slc5a1^{Gt(OST315271)Lex}
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc5a1^{Gt(OST315271)Lex} mutation (1 available); any Slc5a1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:195941 )

• in mice fed a glucose-containing high fat diet

homeostasis/metabolism

abnormal glucose homeostasis ( J:195941 )

• following an oral glucose challenge, mice fed a glucose-free high fat diet exhibit increased intestinal glucose compared with wild-type mice

• however, mice fed a glucose-free high fat diet and treated with streptozotocin exhibit normal increase in blood glucose

abnormal circulating glucose level ( J:195941 )

• in a glucose tolerance test, mice fed a glucose-containing high fat diet exhibit no increase in circulating glucose unlike wild-type mice

decreased circulating insulin level ( J:195941 )

• in mice fed a glucose-containing high fat diet after glucose challenge

improved glucose tolerance ( J:195941 )

• whether fed standard chow or a high fat diet

• in mice fed a glucose-containing high fat diet

growth/size/body

decreased body weight ( J:195941 )

• in mice fed standard chow

slow postnatal weight gain ( J:195941 )

• in mice fed a glucose-containing high fat diet

behavior/neurological

behavior/neurological phenotype ( J:195941 )

N	• mice exhibit normal locomotor activity

decreased food intake ( J:195941 )

• in mice fed a glucose-containing high fat diet

• however, mice fed a glucose-free high fat diet exhibit normal food intake

skeleton

skeleton phenotype ( J:195941 )

N	• mice exhibit normal bone mineral density

long femur ( J:195941 )

• in female, but not male, mice at 47 weeks

increased bone trabecula number ( J:195941 )

• in the fifth lumbar vertebra spine of female, but not male, mice at 47 weeks

digestive/alimentary system

distended cecum ( J:195941 )

• cecal distention in mice fed a glucose-containing high fat diet

limbs/digits/tail

long femur ( J:195941 )

• in female, but not male, mice at 47 weeks

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:195941 )

• during an intraperitoneal glucose tolerance test in fasted mice fed a glucose-free high fat diet

• during a glomerular filtration study most of the 10 h interval of the light cycle in fed mice on a glucose-free high fat diet

decreased circulating insulin level ( J:195941 )

• during an intraperitoneal glucose tolerance test in fasted mice fed a glucose-free high fat diet

improved glucose tolerance ( J:195941 )

• during an intraperitoneal glucose tolerance test in mice fed a glucose-free high fat diet

abnormal urine homeostasis ( J:195941 )

increased urine glucose level ( J:195941 )

• increased urinary glucose excretion in mice fed a glucose-free high fat diet

increased urine chloride ion level ( J:195941 )

• in male, but not female, mice

increased urine potassium level ( J:195941 )

• in male, but not female, mice

increased urine sodium level ( J:195941 )

• in male, but not female, mice

increased urine magnesium level ( J:195941 )

increased urine urea nitrogen level ( J:195941 )

renal/urinary system

abnormal urine homeostasis ( J:195941 )

increased urine glucose level ( J:195941 )

• increased urinary glucose excretion in mice fed a glucose-free high fat diet

increased urine chloride ion level ( J:195941 )

• in male, but not female, mice

increased urine potassium level ( J:195941 )

• in male, but not female, mice

increased urine sodium level ( J:195941 )

• in male, but not female, mice

increased urine magnesium level ( J:195941 )

increased urine urea nitrogen level ( J:195941 )

abnormal bladder urine volume ( J:195941 )

• mice exhibit increased urine volume compared with wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:195941 )

N	• mice exhibit normal locomotor activity

increased food intake ( J:195941 )

• in male, but not female, mice

growth/size/body

decreased body weight ( J:195941 )

• in male, but not female, mice

adipose tissue

decreased total body fat amount ( J:195941 )

• in male, but not female, mice

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