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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ttll1Gt(OST372941)Lex
gene trap OST372941, Lexicon Genetics
MGI:4297933
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ttll1Gt(OST372941)Lex/Ttll1Gt(OST372941)Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:5431239


Genotype
MGI:5431239
hm1
Allelic
Composition		 Ttll1Gt(OST372941)Lex/Ttll1Gt(OST372941)Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ttll1Gt(OST372941)Lex mutation (1 available); any Ttll1 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:186050 )
N
• mice exhibit normal ependymal cell cilia
• female mice exhibit normal fertility
abnormal spermatogenesis ( J:186050 )
• flagellar loss takes place before spermiation of elongate spermatids
• however, spermatogonia morphology is normal during meiosis and mitosis
oligozoospermia ( J:186050 )
• severely reduced
abnormal sperm midpiece morphology ( J:186050 )
• thickened and irregular
absent sperm flagellum ( J:186050 )
• on some sperm
detached sperm flagellum ( J:186050 )
• on some sperm
absent sperm head ( J:186050 )
• on some sperm

growth/size/body
growth/size/body region phenotype ( J:186050 )
N
• mice do not exhibit situs invertus
decreased lean body mass ( J:186050 )
• in male mice
decreased body weight ( J:186050 )
• in male mice

respiratory system
respiratory system phenotype ( J:186050 )
N
• lungs appear normal with no increased susceptibility to inflammation
• mice exhibit normal cilia on respiratory epithelial cells lining the nasal passages and sinuses

hearing/vestibular/ear
increased susceptibility to otitis media ( J:186050 )
• unilateral and bilateral

immune system
increased susceptibility to otitis media ( J:186050 )
• unilateral and bilateral

nervous system
nervous system phenotype ( J:186050 )
N
• mice exhibit normal brain ventricles

cellular
oligozoospermia ( J:186050 )
• severely reduced
abnormal sperm midpiece morphology ( J:186050 )
• thickened and irregular
absent sperm flagellum ( J:186050 )
• on some sperm
detached sperm flagellum ( J:186050 )
• on some sperm
absent sperm head ( J:186050 )
• on some sperm




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory