Phenotypes associated with this allele

• Allele Symbol: Dnajc27^{Gt(OST374030)Lex}
• Allele Name: gene trap OST374030, Lexicon Genetics
• Allele ID: MGI:4298298
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnajc27^Gt(OST374030)Lex/Dnajc27^Gt(OST374030)Lex	involves: 129S5/SvEvBrd * C57BL/6N	MGI:5825361

Genotype
MGI:5825361

hm1

• Allelic Composition: Dnajc27^{Gt(OST374030)Lex}/Dnajc27^{Gt(OST374030)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:210622 )

• upon azoxymethane/dextran sodium sulfate (AOM/DSS) challenge, the incidence and multiplicity of colonic tumors is significantly lower than that in AOM/DSS-treated wild-type controls

decreased tumor growth/size ( J:210622 )

• upon AOM/DSS challenge, both colonic tumor burden and proliferation of colonic epithelial cells are significantly reduced relative to those in AOM/DSS-treated wild-type controls

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:210622 )

• upon azoxymethane/dextran sodium sulfate (AOM/DSS) challenge, the incidence and multiplicity of colonic tumors is significantly lower than that in AOM/DSS-treated wild-type controls

digestive/alimentary system

abnormal enterocyte proliferation ( J:210622 )

• AOM/DSS-treated mice show significantly reduced proliferation of colonic epithelial cells relative to similarly treated wild-type controls, as shown by BrdU staining

cellular

abnormal enterocyte proliferation ( J:210622 )

• AOM/DSS-treated mice show significantly reduced proliferation of colonic epithelial cells relative to similarly treated wild-type controls, as shown by BrdU staining