Analysis Tools
mortality/aging
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• some mice die by P21
• however, mice that survive exhibit normal life expectancy
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nervous system
| N |
• mice exhibit normal prefrontal cortex, cingulate cortex, amygdala, thalamus, nucleus accumbens, motor cortex and neuronal viability
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• failure of neurons to migrate from their birthplace or to stop within their correct layer
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• infrapyramidal mossy fibre tract are misrouted amongst the CA3 neurons compared to in wild-type mice
• misrouted axons form aberrant synapses within the stratum pyramidale
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• disrupted organization
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• diffusely packed
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• split in to a bilaminar stratum
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• in the stratum radiatum and stratum oriens
• in the superficial layer of CA3
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• pyramidal neurons exhibit dendrites with thorny excrescences from the misrouted mossy fibre tracts on both proximal and distal apical dendrites compared with wild-type cells
• however, the number of branch points is normal
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behavior/neurological
| N |
• mice exhibit normal sensorimotor abilities (olfaction, vision, balance and self-righting, eye blink, ear twitch, whisker-orientation and neuromuscular strength) and rearing
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• impaired
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• in a cross-maze, mice exhibit increased latency in reaching the escape platform over the course of the acquisition period, decreased arm choice accuracy and increased escape latency compared with wild-type mice
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• in an elevated plus maze, mice spend more time in open arms and enter them more often with increased head dips and fewer stretched attend postures compared with wild-type mice
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• impaired novel object recognition when presented with a familiar and new object
• hyperactivity in the object recognition test with longer exploration time in both phases of the trial
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• increased distance traveled in an open field in male and female mice
• hyperactivity in the object recognition test with longer exploration time in both phases of the trial
• increased activity in an elevated plus maze
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growth/size/body
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• from P14 onward
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• at P14
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cellular
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• failure of neurons to migrate from their birthplace or to stop within their correct layer
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| schizophrenia | DOID:5419 |
OMIM:181500 |
J:217297 | |
